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Completed

NCT Number: NCT01039935

Genetic Basis of Odor Discrimination

Prior to the main study we will perform a pilot study on 60 subjects. The purpose of the pilot study is to identify the range of odor concentrations that will be used in the main study and to optimize the tasks performed in the main study.

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Key information

Conditions

Non-smokers

Age range

18 year–50 year

Sex eligibility

All sexes

Study type

Observational

Primary location

The Rockefeller University

New York, 10065, United States

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Age 18-50
  • Current non-smokers

Exclusion criteria

  • Current smokers
  • Allergy to fragrances or smells of any kind
  • Active head cold, upper respiratory infection, or seasonal nasal allergies
  • History of nasal health problems, including endoscopic nasal surgery for sinus conditions or polyp removal.
  • Pre-existing medical condition that has caused anosmia or near total loss of the sense of smell, such as: head injury, cancer therapy, radiation to head and neck, or alcoholism

Treatment and study plan

Primary outcomes

  1. Percentage of correct responses when discriminating between (-)-carvone and (+)-carvone, isovaleric acid and isobutyric acid, androstenone and androstadienone DNA sequence of ORs sensitive to these odors

    Time frame: 3 years

Secondary outcomes

  1. concentration at which odors need to be added to allow for discrimination; thresholds to all six odors; verbal descriptors assigned to all six odors

    Time frame: 3 years

Sponsors and collaborators

Lead sponsor

Rockefeller University

Other

Registry information

Important dates

Study start
2009
Primary completion
2012
Study completion
2012
First posted
Dec 25, 2009
Registry last updated
Sep 6, 2012

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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