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OpenTrials
Completed

NCT Number: NCT03768284

Genetic Analysis of Pediatric Psoriasis

This study will ascertain approximately 150 subjects, which will include pediatric psoriasis patients diagnosed before age 12, parents not affected by psoriasis, and if a family history is indicated, up to third-degree family members. Saliva (or buccal swabs in the case of infants) will be obtained for DNA isolation.

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Key information

Conditions

Psoriasis Skin Diseases Skin Diseases, Papulosquamous Skin and Connective Tissue Diseases

Sex eligibility

All sexes

Study type

Observational

Primary location

Ann & Robert H. Lurie Children's Hospital of Chicago

Chicago, Illinois, 60611, United States

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Patients (of any age) who developed psoriasis before 12 years of age and who have no family history of psoriasis in either parent.
  • Parents of patients who developed psoriasis before 12 years of age
  • Up to third-degree family members (first cousin, grandparent, great-grandparent) with or without psoriasis, if family history is indicated.

Exclusion criteria

  • Patients, parents, and other family member unable to give a saliva or buccal swab sample.
  • Patients, parents, and other family member unable to give written informed consent.

Treatment and study plan

Saliva or buccal sample

Other

Saliva or buccal sample

Primary outcomes

  1. CARD14 mutations

    Time frame: one year

    The number of pathogenic mutations identified in CARD14 in a pediatric psoriasis cohort

Secondary outcomes

  1. De novo mutations

    Time frame: one year

    The number of candidate psoriasis genes through the identification of de novo mutations in moderate-to-severe pediatric cases who require systemic intervention.

Sponsors and collaborators

Lead sponsor

Northwestern University

Other

Collaborators

  • Icahn School of Medicine at Mount Sinai
  • National Psoriasis Foundation

Registry information

Important dates

Study start
2018
Primary completion
2021
Study completion
2021
First posted
Dec 7, 2018
Registry last updated
Apr 20, 2022

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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