Genetic an Functional Studies of Patient With Inflammatory Bowel Disease

The objective of this study is to study the response of macrophages, isolated from patients with ulcerative colitis (Crohn's disease) or Crohn's disease (CD), to 6 candidate enterogenous and their derivatives, depending on the genotype for associated polymorphisms. to the development of IBD

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Key information

Conditions

Inflammatory Bowel Diseases Colitis Colitis, Ulcerative Colonic Diseases Crohn Disease Digestive System Diseases Gastroenteritis Gastrointestinal Diseases Intestinal Diseases

Age range

6 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

CHRU, Hôpital Claude Huriez

Lille, France

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

patient with definite crohn's disease or ulcerative colitis

Exclusion criteria

patient receiving anti-TNF therapy during 14 days before inclusion.

Treatment and study plan

Primary outcomes

Isolated macrophage response measured by PCR

Time frame: Baseline: one session

identification of macrophage activation markers specific analysis of gene expression (by PCR in real time) and / or the production (ELISA) of proinflammatory molecules (IL-6, TNF-1 and IL-8), anti-inflammatory (IL-10) and immunomodulatory (IL4,PPAR -2, MOR)

Sponsors and collaborators

Lead sponsor

University Hospital, Lille

Other

Registry information

Acronym: MINOTOR

Important dates

Study start: 2007
Primary completion: 2017
Study completion: 2017
First posted: Nov 23, 2018
Registry last updated: Nov 23, 2018

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed