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Completed

NCT Number: NCT01978717

General Anesthesia Combined With Epidural Anesthesia Mitigates the Surgical Stress-related Immunosuppression in Patients With Colorectal Cancer

The purpose of this study is to prove whether general anesthesia combined with epidural anesthesia could better maintain body balance of Th1/Th2 and Treg/Th17 compared with general anesthesia, so as to reduce the surgical stress-related immunosuppression, and to improve the prognosis.

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Key information

Conditions

Colorectal Neoplasms Colonic Diseases Digestive System Diseases Digestive System Neoplasms Gastrointestinal Diseases Gastrointestinal Neoplasms Intestinal Diseases Intestinal Neoplasms Neoplasms Neoplasms by Site Rectal Diseases

Age range

51 year–65 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Zhong Shan Hospital Fudan University

Shanghai, Shanghai Municipality, 200032, China

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • patients with Colorectal Cancer(CRC);
  • subjected to the Fast-Track processing of surgery;
  • between 18 and 75 years old.

Exclusion criteria

  • American Society of Anesthesiologists(ASA) grade > III;
  • BMI > 30;
  • a history of abdominal surgery, endocrine or immune system dysfunction;
  • recent blood transfusions, hormone or non-steroidal anti-inflammatory therapy during the past month;
  • previous contraindication to epidural anesthesia.

Treatment and study plan

epidural anesthesia

Procedure

General Anesthesia

Procedure

Patients received general anesthesia for surgery

Primary outcomes

  1. The changes of peripheral immune cells and cytokines

    Time frame: within the first 5 days after surgery

    The changes of peripheral subtype of T-helper, myeloid-derived suppressor cells(MDSCs) and cytokines

Sponsors and collaborators

Lead sponsor

Changhong Miao

Other

Registry information

Important dates

Study start
2011
Primary completion
2012
Study completion
2012
First posted
Nov 7, 2013
Registry last updated
Nov 7, 2013

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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