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Enrolling by Invitation

NCT Number: NCT02564692

GeneMatch: A Program of the Alzheimer's Prevention Registry to Match Individuals to Studies Based on Apolipoprotein E (APOE) Genotype

The purpose of the Alzheimer's Prevention Registry GeneMatch program is to identify a large group of people interested in participating in research studies or clinical trials based in part on their genetic background. This genetic information will be used to match interested individuals to studies, providing a recruitment resource to the Alzheimer's scientific community. Interested individuals should visit www.endALZnow.org/GeneMatch to join the GeneMatch program.

Enrolling by Invitation

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Key information

Conditions

Alzheimer Disease Brain Diseases Central Nervous System Diseases Dementia Mental Disorders Nervous System Diseases Neurocognitive Disorders Neurodegenerative Diseases Tauopathies

Age range

50 year–90 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Banner Alzheimer's Institute

Phoenix, Arizona, 85006, United States

About this study

The primary objectives of the Alzheimer's Prevention Registry GeneMatch program are to (1) identify and characterize a large cohort of people who are interested in, and may be eligible to participate in, current and future preclinical Alzheimer's disease research studies and clinical trials based on their genetic background, and (2) provide information to these individuals about research studies for which they may be eligible, based in part on their genetic background. Cognitively unimpaired individuals age 50 to 90, inclusive, are eligible to enroll in GeneMatch. GeneMatch will provide participants with a genetic sample kit (a cheek swab) to test for a specific gene called apolipoproteins E (APOE). GeneMatch does not disclose the results of the APOE test to participants. GeneMatch may use the APOE test results to match participants to research studies. Participants are under no obligation to pursue these study opportunities.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Age 50-90, inclusive
  • Provide basic demographic, medical history, and contact information
  • Consent to APOE genotyping without receiving results
  • Live in the United States

Exclusion criteria

  • Unable to comply with this project's protocol requirements
  • Self-reported diagnosis of dementia or any other objective cognitive impairment syndrome

Treatment and study plan

Primary outcomes

  1. Number of individuals who enroll in GeneMatch

    Time frame: 15 years

Secondary outcomes

  1. Number of individuals referred to research studies

    Time frame: 15 years

  2. Number of individuals who enroll in research studies

    Time frame: 15 years

Sponsors and collaborators

Lead sponsor

Banner Health

Other

Registry information

Official study title

Alzheimer's Prevention Registry GeneMatch Program

Important dates

Study start
2015
Primary completion
2030
Study completion
2030
First posted
Oct 1, 2015
Registry last updated
Dec 9, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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