Skip to main content
OpenTrials
Not Yet Recruiting

NCT Number: NCT06091878

Gene Expression Profiling in a Validation Cohort of Locally Advanced and Recurrent/Metastatic Salivary Gland Cancers

The INDAGA-UK trial is a retrospective, multi-centre observational study in participants with locally advanced and recurrent salivary gland to investigate t its molecular profiling, and to explore new prognostic and druggable markers. We will analyse samples and data from patients diagnosed with salivary gland cancer from 2013 - 2023. Subject and sample identification will occur over a 12-month period. Samples and data will be analysed over the next 12 months prior to study end.

Not Yet Recruiting

Trial opening soon.

Get Notified

Key information

Conditions

Salivary Gland Cancer Head and Neck Neoplasms Mouth Diseases Mouth Neoplasms Neoplasms Neoplasms by Site Salivary Gland Diseases Salivary Gland Neoplasms Stomatognathic Diseases

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Who can participate

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Aged over 18
  • Histological diagnosis of salivary gland cancer (SGCs)
  • Availability of archival tissue (acceptable after 2013 up to present)
  • Ability to give informed consent (if applicable)* for retrieving histological specimen and preform molecular analysis *De-identified archival tissue from deceased patients will be collected as part of the study once REC approval is in place, if the patient was alive when the samples were taken and they are not part of the NHS opt out scheme.

Exclusion criteria

  • Different H&N cancer of other histology
  • Thyroid cancers

Treatment and study plan

observation

Other

Observational study, no intervention

Primary outcomes

  1. • Description of the molecular and genomic profile of locally advanced and recurrent-metastatic SGCs.

    Time frame: Time Frame: Through study completion, expected duration of 10 years

    • Description of the molecular and genomic profile of locally advanced and recurrent-metastatic SGCs.

Study contacts

Contact information is provided by the study sponsor or research team.

Pablo Jimenez

CONTACT

[email protected]

02073528171

Sarah Burton

CONTACT

[email protected]

02073528171

Sponsors and collaborators

Lead sponsor

Royal Marsden NHS Foundation Trust

Other

Registry information

Official study title

Gene Expression Profiling in a Validation Cohort of Locally Advanced and Recurrent/Metastatic Salivary Gland Cancers: The INDAGA-UK Trial

Acronym: INDAGA-UK

Important dates

Study start
2024
Primary completion
2025
Study completion
2026
First posted
Oct 19, 2023
Registry last updated
Aug 9, 2024

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Related clinical trials

Published trials that share one or more normalized conditions with this study.