Gene Expression Profiles in Predicting Survival of Patients With Head and Neck Cancer

RATIONALE: Studying samples of tumor tissue from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer. It may also help doctors predict survival of patients with head and neck cancer.

PURPOSE: This laboratory study is assessing gene expression profiles in predicting survival of patients with head and neck cancer.

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Key information

Conditions

Head and Neck Cancer Carcinoma Carcinoma, Squamous Cell Head and Neck Neoplasms Neoplasms Neoplasms by Histologic Type Neoplasms by Site Neoplasms, Glandular and Epithelial Squamous Cell Carcinoma of Head and Neck

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

About this study

OBJECTIVES:

Identify gene expression profiles associated with survival by DNA microarray assay analysis using RNA from formalin-fixed paraffin-embedded tissue samples from patients with squamous cell carcinoma of the head and neck treated on clinical trial RTOG-9501.

OUTLINE: Formalin-fixed paraffin-embedded tissue samples are analyzed by DNA microarray analysis for gene expression profiling.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Diagnosis of squamous cell carcinoma of the head and neck, including 1 of the following sites:

Hypopharynx
Larynx
Oral cavity
Oropharynx
Stage II-IV disease
Must have received treatment on clinical trial RTOG-9501
Formalin-fixed paraffin-embedded tissue samples available

Exclusion criteria

Not specified

PRIOR CONCURRENT THERAPY:

Not specified

Treatment and study plan

microarray analysis

Genetic

Assay RNA obtained from archived formalin fixed paraffin embedded tissue samples

laboratory biomarker analysis

Other

The gene expression data will be linked to the clinical information in order to generate profile of recurrence and survival as a biomarker.

Primary outcomes

Identification of gene expression profiles used to predict survival as assessed by DNA microarray analysis

Time frame: at time of surgical resection

Sponsors and collaborators

Lead sponsor

Vanderbilt-Ingram Cancer Center

Other

Collaborators

National Cancer Institute (NCI)

Registry information

Official study title

Survival Prediction in HNSCC Based on Gene Expression Profiles From FFPE Tissues

Important dates

Study start: 2005
Primary completion: 2007
Study completion: 2007
First posted: May 12, 2009
Registry last updated: Sep 10, 2012

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed