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Completed

NCT Number: NCT02467283

Gene Expression Profiles in Chronic Periodontitis

Current concepts of the causes of periodontitis implicate a bacterial infection as the primary cause of the disease. Several bacterial species residing in a biofilm on tooth surfaces are closely associated with periodontitis. Chronic periodontitis (CP) is initiated and sustained by bacterial plaque, but host defense mechanisms play an integral role in its pathogenesis.

Gene expression profiling is a powerful means of generating comprehensive genome-level data sets on diseases such as cancer, asthma, rheumatoid disorders and periodontitis, and provides significant insight information for these diseases. Gene expression profiling may provide an evidence for involving genes in the pathogenesis of CP and generate further information other than clinical signs and symptoms of CP.

The aim of this study was to identify gene-expression patterns of patients with chronic periodontitis by whole-transcriptome gene-expression analyses.

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Key information

Conditions

Chronic Periodontitis Chronic Disease Disease Attributes Inflammation Mouth Diseases Pathologic Processes Pathological Conditions, Signs and Symptoms Periodontal Diseases Periodontitis Stomatognathic Diseases

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • CP patients had at least 20 teeth exhibiting >30% of measured sites with >5mm clinical attachment loss.
  • Had bleeding on probing (BOP) at >50% of the proximal sites.

Exclusion criteria

  • Had any known systemic diseases that can influence the periodontal status, oral diseases other than chronic periodontitis and ongoing orthodontic therapy.
  • History of hepatitis, HIV infection, or diabetes; requirement for antibiotic prophylaxis, pregnancy or lactation; and long-term use of anti-inflammatory drugs.
  • Should be free of systemic diseases
  • Individuals had to be older than 18 years of age.

Treatment and study plan

Genom-based whole-genome transcriptomic

Genetic

Gene expression profiling is a powerful means of generating comprehensive genome-level data sets.

Primary outcomes

  1. mRNA quantification

    Time frame: 2 months

Secondary outcomes

  1. Gen networking map

    Time frame: 2 months

Sponsors and collaborators

Lead sponsor

Kocaeli University

Other

Registry information

Official study title

Gene Expression Profiles in Chronic Periodontitis: A Gene Network-based Microarray Analysis

Important dates

Study start
2013
Primary completion
2015
Study completion
2017
First posted
Jun 10, 2015
Registry last updated
Feb 12, 2018

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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