Gene Expression Analysis of the Endometrium After Endometrial Biopsy in Fertile Women

The aim of this study is to evaluate the gene expression of the endometrium after an endometrial biopsy in fertile women using Next Generation Sequencing of total RNA.

Completed

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Key information

Conditions

Infertility Genital Diseases Urogenital Diseases

Age range

18 year–40 year

Sex eligibility

Female

Study type

Interventional

Phase

Not applicable

Primary location

Fertility Clinic Horsens Hospital

Horsens, Denmark

About this study

An endometrial biopsy is done at cycle day LH+7 and repeated in the next cycle at cycle day LH+7.

Tissue is analysed and compared for changes in gene expression profile using Seq RNA

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Fertile women
Age: 18-40 years
BMI: 18-32
Regular menstrual cycle
No use of hormonal contraceptives or IUD the last 3 months

Exclusion criteria

Patients in need of a interpreter
Suspected intrauterine abnormalities
Pregnancy

Treatment and study plan

endometrial biopsy

Procedure

Other names: Pipelle de Cornier

Primary outcomes

Gene Expression of the Endometrium after an endometrial biopsy

Time frame: 1 month between each biopsy

An endometrial biopsy is done at cycle day LH+7 and repeated in the next cycle at cycle day LH+7.

Endometrial tissue is analysed for changes in gene expression profile of various chemokines and cytokines using RNA Sequencing technology

Sponsors and collaborators

Lead sponsor

University of Aarhus

Other

Registry information

Important dates

Study start: 2014
Primary completion: 2016
Study completion: 2016
First posted: Aug 18, 2014
Registry last updated: Jan 31, 2017

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed