NCT Number: NCT05716412
Gene-environment Interactions in Families With Adolescents (Gen-omgevingsinteracties in Gezinnen Met Adolescenten)
English:
The main purpose of this study is to investigate the developmental trajectories of parents and adolescents in the Flemish region of Belgium. The investigators will focus on the role of genetic factors, environmental factors (e.g. parental rearing styles), and the interaction between these factors. Specifically, it will be investigated were difficulties or strengths in the development of adolescents can be attributed to. How an individual's genetic characteristics and his/her family environment can interact, will also be monitored. This study is closely related to the Leuvense Adoption Study (http://leuvenseadoptiestudie.be/). Just like this research, the investigators will take child and parent factors in account, as well as their interaction. The investigators will not only focus on vulnerability, but also on protective factors that can give resilience to both parents and children. The theoretical framework of this study is twofold. (1) In the development of children, genes and environment are interwoven in a dynamical relation. Neither genes or environment alone can explain how a child will develop over time. (2) The relation between genetic and environmental factors can be expressed in different ways. On the one hand, a certain genetic contribution can impact the way parents will uphold a certain parental rearing style. On the other hand, having certain genetic characteristics will have consequences for how adolescents will react to their environment. For example, a certain parental rearing style will strengthen some adolescents resilience, but for other adolescents this could equally lead to a more maladaptive development. Thus, depending on his or her genetic endowment, a child will develop differently given a certain family environment.
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Notify MeKey information
Conditions
Age range
12 year and older
Sex eligibility
All sexes
Study type
Observational
Primary location
University of Gent - Faculty of Psychology and Educational Sciences - Department of Developmental-, Personality- and Social Psychology, Ghent, Oost-Vlaanderen, Belgium
Who can participate
Healthy volunteers accepted: Yes
Only the study team can determine whether someone qualifies for participation.
Inclusion criteria
- Adolescents adopted before the age of one and currently 12 to 18 years old (from international adoption) and their adoptive parents
- Matched community sample of adolescents between the age of 12 and 18 years old and their biological related parents
Exclusion criteria
- Major medical or psychiatric disease
Treatment and study plan
Primary outcomes
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Beck's Depression Inventory / Children's Depression Inventory
Time frame: current symptoms, measured once after enrollment
Dimensional assessment and cut-off scores using Beck's Depression Inventory for the adults and Kovacs' Children's Depression Inventory for the adolescents.
Secondary outcomes
-
Somatic Symptoms Questionnaire
Time frame: current complaints, measured once after enrollment
Pain and fatigue related complaints. Sometimes referred to as somatic complaints.
-
Depressive Experiences Questionnaire: self-criticism and dependency
Time frame: measured once after enrollment
Personality assessment by Blatt's polarities of experience model. Blatt's model is a two-polarity model: relatedness (dependency) and self-definition (self-criticism).
Sponsors and collaborators
Lead sponsor
Universitaire Ziekenhuizen KU Leuven
Other
Collaborators
- Fund for Scientific Research, Flanders, Belgium
Registry information
Official study title
Personality and Vulnerability for Affective Spectrum Disorders and Complaints: The Role of Gene-Environment Correlations (rGE) and Interactions (GxE)
Acronym: GiGA
Important dates
- Study start
- 2014
- Primary completion
- 2017
- Study completion
- 2017
- First posted
- Feb 8, 2023
- Registry last updated
- Feb 8, 2023
OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.
View the official ClinicalTrials.gov record (opens in a new tab)This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.