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Completed

NCT Number: NCT03035981

Gastric Emptying of Rice With Different Starch Properties

Glycemic carbohydrates are associated with metabolic disturbances, such as type II diabetes, due to rapid digestion of starch into glucose. The specific properties of starch within these foods has been studied for the purpose of slowing their digestion rate and improving related physiological outcomes, such as gastric emptying rate. The current study investigated the relationship among starch digestion, gastric emptying rate and satiety in white and brown rice.

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Key information

Age range

18 year–50 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

About this study

Studies have indicated that starch-based foods with somewhat high amylose content have slower in vitro starch digestion rates, which relate to a low glycemic response. Low glycemic response is associated with delayed gastric emptying rate as well. Therefore, we hypothesized that rice with a slow starch digesting property would delay gastric emptying. White and brown rice with varying amylose contents were used in this study. A 13C-labeled octanoic acid breath test method was used to measure gastric emptying rate, and questionnaires were used to assess hunger and fullness during the testing sessions. Twelve healthy volunteers were recruited to participate in a crossover design study with six rice treatments and outcome measurements were gastric emptying and satiety assessments. One fermentable carbohydrate (fructooligosaccharide, FOS) solution was used to validate the production of breath hydrogen.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Normal body mass index (18 kg/m2 ≤ BMI ≤ 25 kg/m2)

Exclusion criteria

  • Under any medication
  • History of any gastrointestinal disease or surgery
  • Diabetes
  • Smoker

Treatment and study plan

White rice, low amylose

Other

White and brown rice were tested for differences in gastric emptying rate and appetitive response

White rice, high amylose

Other

White and brown rice were tested for differences in gastric emptying rate and appetitive response

White rice, slow

Other

White and brown rice were tested for differences in gastric emptying rate and appetitive response

White rice, resistant

Other

White and brown rice were tested for differences in gastric emptying rate and appetitive response

Brown rice, low amylose

Other

White and brown rice were tested for differences in gastric emptying rate and appetitive response

Brown rice, high amylose

Other

White and brown rice were tested for differences in gastric emptying rate and appetitive response

Fructooligosaccharide (FOS)

Other

White and brown rice were tested for differences in gastric emptying rate and appetitive response

Primary outcomes

  1. Gastric emptying

    Time frame: Acute study, 4 hours after consumption of test food

    Breath test was performed using 13C-octanoic acid mixed into test meals

  2. Appetitive response

    Time frame: Acute study, 4 hours after consumption of test food

    Fullness and hunger questionnaire was given at various time points after consumption of test foods

Secondary outcomes

  1. Breath hydrogen

    Time frame: Acute study, 4 hours after consumption of test food

    Hydrogen breath test was performed following ingestion of test meals

Sponsors and collaborators

Lead sponsor

Purdue University

Other

Registry information

Official study title

Assessment of Gastric Emptying and Fullness of Rice With Different Starch Properties

Important dates

Study start
2014
Primary completion
2014
Study completion
2014
First posted
Jan 30, 2017
Registry last updated
Jan 30, 2017

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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