Skip to main content
OpenTrials
Recruiting

NCT Number: NCT07535177

Gas6 and Soluble MerTK in Periodontal Diseases

This study aimed to investigate gingival crevicular fluid (GCF) and serum soluble MerTK (sMerTK) and Gas6 levels in periodontal health and disease. A total of 90 individuals, 30 patients with stage III grade B periodontitis, 30 with gingivitis and 30 periodontally healthy individuals were included. Whole-mouth and site-specific clinical periodontal parameters including probing depth, clinical attachment level, bleeding on probing, gingival index, plaque index were recorded. GCF and serum sMerTK and Gas6 levels were measured by enzyme-linked immunosorbent assay. Statistical analysis was performed by using non-parametric tests.

Recruiting

Interested in participating?

Request Info

Key information

Conditions

Periodontitis Mouth Diseases Periodontal Diseases Stomatognathic Diseases

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Bolu Abant Izzet Baysal University Faculty of Dentistry

Bolu, 14030, Turkey (Türkiye)

Location status: Recruiting

Location contact

Nuray Ercan, Assist. Prof.

CONTACT

[email protected]

+905557153767

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Individuals without systemic diseases that may affect periodontal tissues (such as cardiovascular diseases, atherosclerosis, immune system disorders, rheumatoid arthritis, obesity, cancer, and diabetes)
  • Individuals who have not used antibiotics within the last 3 months
  • Individuals not taking any medications known to affect periodontal tissues
  • Individuals without infectious diseases such as HIV, hepatitis B virus (HBV), or tuberculosis
  • Individuals with at least 16 natural teeth, excluding third molars
  • Individuals aged 18 years and older

Exclusion criteria

  • Pregnant or lactating individuals
  • Individuals who have received periodontal treatment within the last 6 months
  • Current smokers

Treatment and study plan

gingival crevicular fluid collection

Other

Gingival crevicular fluid collection using sterile paper strips inserted into the gingival sulcus for 30 seconds from selected periodontal sites (healthy, gingivitis, and periodontitis) for biomarker analysis (Gas6 and sMerTK).

Primary outcomes

  1. Gas6 Levels in Gingival Crevicular Fluid

    Time frame: baseline

    Quantitative measurement of Gas6 levels (pg/mL) in gingival crevicular fluid samples using enzyme-linked immunosorbent assay (ELISA), and comparison of these levels among periodontally healthy, gingivitis, and periodontitis groups.

  2. Soluble MerTK (sMerTK) Levels in Gingival Crevicular Fluid

    Time frame: baseline

    Quantitative measurement of soluble MerTK (sMerTK) levels (pg/mL) in gingival crevicular fluid samples using enzyme-linked immunosorbent assay (ELISA), and comparison of these levels among periodontally healthy, gingivitis, and periodontitis groups.

Secondary outcomes

  1. Plaque Index

    Time frame: baseline

    Measurement of plaque index (score) in participants with periodontal health, gingivitis, and periodontitis, and evaluation of its correlation with gingival crevicular fluid Gas6 and soluble MerTK levels.

  2. Probing Depth

    Time frame: baseline

    Measurement of probing depth (mm) in participants with periodontal health, gingivitis, and periodontitis, and evaluation of its correlation with gingival crevicular fluid Gas6 and soluble MerTK levels.

  3. Clinical Attachment Loss

    Time frame: baseline

    Measurement of clinical attachment loss (mm) in participants with periodontal health, gingivitis, and periodontitis, and evaluation of its correlation with gingival crevicular fluid Gas6 and soluble MerTK levels.

  4. Gingival Index

    Time frame: baseline

    Measurement of gingival index (score) in participants with periodontal health, gingivitis, and periodontitis, and evaluation of its correlation with gingival crevicular fluid Gas6 and soluble MerTK levels.

Sponsors and collaborators

Lead sponsor

Abant Izzet Baysal University

Other

Registry information

Official study title

Evaluation of Gas6 and Soluble MerTK Levels in Gingival Crevice Fluid in Individuals With Periodontal Health, Gingivitis, and Periodontitis

Important dates

Study start
2026
Primary completion
2026
Study completion
2026
First posted
Apr 16, 2026
Registry last updated
Apr 16, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Related clinical trials

Published trials that share one or more normalized conditions with this study.