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NCT Number: NCT06755502

Garlic Oil As Root Filling Material in Primary Molars

The goal of this study is to test garlic oil mixed with zinc oxide as a potential root canal filling material of primary molars in children aged from four to eight years.

the study hypothesized that garlic oil mixed with zinc oxide would be the same as the gold standard filling material (metapex).

The group receiving the garlic oil with zinc oxide as root canal filling material will be compared with other similar group receiving metapex as root canal filling material in terms of clinical and radio-graphic success, and working time.

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Key information

Conditions

Irreversible Pulpitis (Toothache) Facial Pain Neurologic Manifestations Pain Pathological Conditions, Signs and Symptoms Signs and Symptoms Stomatognathic Diseases Tooth Diseases Toothache

Age range

4 year–8 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

About this study

This study is a randomized clinical trial (RCT), that aims compare the clinical and radio-graphic success of garlic oil mixed with zinc oxide, used as root canal filling material in primary molars in children aged from four to eight years, with the conventional root filling material, which is metapex.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Primary second molars which are diagnosed with irreversible pulpitis, or pulp necrosis.
  • Presence of sinus tract.
  • Periapical bone swelling.
  • Continuous bleeding after amputation of the coronal pulp tissue.
  • No pulp tissue remains when the pulp chamber is accessed.
  • Pus discharges from the canal.
  • Radiographically, only primary molars with at least two-thirds of the root length.
  • Presence of inter-radicular or periapical radiolucency.

Exclusion criteria

  • A tooth with internal root resorption will not be included. 2. Excessive tooth mobility beyond healing. 3. Carious perforation in the pulpal flour. 4. A tooth with a pathological lesion extending to the successor's tooth germ. 5. Non-restorable primary molars.

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Treatment and study plan

Garlic oil

Combination Product

garlic oil mixed with zinc oxid powder, as root canal filling material

Calcium Hydroxide, Iodoform, paste

Drug

Metapex as root canal filling materials

Other names: metapex

Primary outcomes

  1. The clinical success rate

    Time frame: 3, 6,9,and 12 months

    The criteria of successful treatment, according to which the clinical evaluation will be done, will be "No abnormal mobility", "No sensitivity to percussion", and "No swelling"

  2. Radio-graphic success

    Time frame: 6, and 12 month.

    For the radiographic success, the evaluation criteria will be "Preoperative pathological inter-radicular and/or periapical radiolucency started to resolve, or remained the same size", "No new postoperative pathological radiolucency developed", and "No pathological internal or external root resorption"

Study contacts

Contact information is provided by the study sponsor or research team.

Mennat Allah A. A. Elkareem

CONTACT

[email protected]

+20 1026022605

Sponsors and collaborators

Lead sponsor

Cairo University

Other

Registry information

Official study title

Evaluation of Allium Sativum As Root Filling Material for Primary Molars Indicated for Non Vital Pulp Therapy: Randomized Clinical Trials

Important dates

Study start
2025
Primary completion
2026
Study completion
2026
First posted
Jan 1, 2025
Registry last updated
Mar 20, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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