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Completed

NCT Number: NCT03903861

Galactose Mediated Glycogen Resynthesis

This study will compare short-term post-exercise muscle glycogen synthesis following combined galactose-glucose, glucose alone or galactose alone ingestion.

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Key information

Conditions

Exercise Behavior Motor Activity

Age range

18 year–45 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

School of Sport, Exercise and Rehabilitation Sciences

Birmingham, West Midlands, B15 2TT, United Kingdom

About this study

Lactose, the sugar contained within milk, consists of glucose and galactose. Post-exercise consumption of a carbohydrate mixture containing glucose with galactose has been shown to accelerate liver glycogen repletion as compared to glucose-only provision. However, the extent to which galactose-glucose combinations influence post-exercise muscle glycogen storage has yet to be determined.

Therefore, this study will investigate whether short-term muscle glycogen storage after strenuous endurance exercise is enhanced by combined galactose-glucose or glucose only ingestion as compared to the ingestion of galactose alone.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

.

  • Body mass index in the range: 18.5 - 27.5 kg/m2
  • Participates in endurance-based exercise (e.g. cycling, running, rowing) at least 3 times per week
  • Aerobic fitness: VO2max >45 ml/kg/min (men), >40 ml/kg/min (women)

Exclusion criteria

  • Lidocaine allergy
  • Current participation in another scientific/clinical study
  • Bleeding disorder/s
  • Current or recent smoker to include vaping (last 60 days)
  • Vegan
  • Existence of food intolerances
  • Poor recent health as indicated in the general health questionnaire
  • Engage in uncommon eating practices (e.g. sustained periods of fasting)
  • Diagnosed with galactosemia

Treatment and study plan

Glucose alone

Other

Young men or women will complete a glycogen depleting bout of exercise followed by the provision of glucose-alone over 4 hours of recovery before a subsequent bout of exercise.

Galactose alone

Other

Young men or women will complete a glycogen depleting bout of exercise followed by the provision of galactose-alone over 4 hours of recovery before a subsequent bout of exercise.

Glucose and galactose

Other

Young men or women will complete a glycogen depleting bout of exercise followed by the provision of glucose and galactose over 4 hours of recovery before a subsequent bout of exercise.

Primary outcomes

  1. Muscle glycogen synthesis rates (mmol/kg/dm/h)

    Time frame: 4 hours

    Muscle glycogen synthesis rates over the post-exercise recovery period

Secondary outcomes

  1. Carbohydrate oxidation rates (g/min)

    Time frame: Up to 90 minutes

    Total, exogenous and endogenous carbohydrate oxidation during a secondary bout of exercise

  2. Fat oxidation rates (g/min)

    Time frame: Up to 90 minutes

    Fat oxidation during a secondary bout of exercise

  3. Plasma glucose (mmol/L)

    Time frame: Up to 6 hours

    Plasma glucose during the post-exercise recovery period and during a secondary bout of exercise

  4. Serum insulin (mU/L)

    Time frame: Up to 6 hours

    Serum insulin during the post-exercise recovery period and during a secondary bout of exercise

  5. Plasma galactose (mmol/L)

    Time frame: Up to 6 hours

    Plasma galactose during the post-exercise recovery period and during a secondary bout of exercise

  6. Plasma lactate (mmol/L)

    Time frame: Up to 6 hours

    Plasma lactate during the post-exercise recovery period and during a secondary bout of exercise

  7. Plasma non-esterified fatty acids (mmol/L)

    Time frame: Up to 6 hours

    Plasma non-esterified fatty acids during the post-exercise recovery period and during a secondary bout of exercise

  8. Plasma glycerol (umol/L)

    Time frame: Up to 6 hours

    Plasma glycerol during the post-exercise recovery period and during a secondary bout of exercise

  9. Plasma glucagon (pmol/L)

    Time frame: Up to 6 hours

    Plasma glucagon during the post-exercise recovery period and during a secondary bout of exercise

Sponsors and collaborators

Lead sponsor

University of Birmingham

Other

Collaborators

  • Dairy Management Inc.

Registry information

Official study title

Galactose Mediated Glycogen Resynthesis and the Effects on Metabolism During Subsequent Exercise

Important dates

Study start
2019
Primary completion
2020
Study completion
2020
First posted
Apr 4, 2019
Registry last updated
Jan 4, 2023

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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