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OpenTrials
Completed

NCT Number: NCT02063373

Gait, Stair Climbing and Postural Stability in Knee Osteoarthritis Patients After Hyaluronic Acid Injection

Treatment: five intro-articular Hyaluronic Acid injection

Assessment has two parts, that are as follow:

1. Postural stability and risk of fall assessment using Biodex stability index and "Timed up and Go" test 2. Gait and stair climbing assessment using Vicon motion capture system synchronized with four force plates.

For knee OA subjects, assessment was done in week one or before injection; and for healthy controls one assessment was performed.

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Key information

Conditions

Bilateral Knee Osteoarthritis

Age range

50 year–70 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Phase 3

About this study

This study aimed to assess the effect of hyaluronic acid injection on Postural stability, biomechanics of gait and stair climbing in individuals with bilateral knee osteoarthritis (OA).

Participants were individuals with knee OA (control and treatment) and healthy people.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Mild and moderate bilateral knee osteoarthritis
  • Age between 50 and 70 years

Exclusion criteria

  • Recent Lower limb injury
  • Diabetic
  • Knee or hip replacement
  • Knees HA injection in last 6 months
  • Any neuromuscular disease such as stroke and Parkinson

Treatment and study plan

Hyaluronic acid

Other

treatment: Weekly intra-articular hyaluronic acid injection (20 MG / 2ML) into both knees for five weeks.

Other names: Hyalgan, Manufacturer: Fidia Pharmaceutici S.p.A, Italy

Primary outcomes

  1. Change in Postural stability after treatment

    Time frame: baseline and 6 weeks

  2. Changes in Biomechanics of gait after treatment

    Time frame: baseline and 6 weeks

  3. Changes in biomechanics of stair climbing after treatment

    Time frame: baseline and 6 weeks

Secondary outcomes

  1. Change in Pain after treatment

    Time frame: baseline and 6 weeks

  2. Changes in WOMAC scores after treatment

    Time frame: baseline and 6 weeks

Sponsors and collaborators

Lead sponsor

University of Malaya

Other

Registry information

Important dates

Study start
2012
Primary completion
2013
First posted
Feb 14, 2014
Registry last updated
Feb 14, 2014

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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