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NCT Number: NCT05908279

Gait Control in Parkinson Disease

Previous work has shown that a statistical property of gait characterised by long-range autocorrelation functions is altered in Parkinson disease (PD). On the other hand it has been suggested that the same property is linked to the ability in healthy humans to co-regulate the amplitude and cadence of strides towards maintaining a constant speed. Here the investigators want to better understand why it is altered in PD by measuring the transitions between gait instructed by a metronome, and gait without metronome. The experimental conditions will allow the comparisons between these transitions across PD and healthy groups of volunteers, and assess differences based on statistical and computational modelling. The link with potential freezing episodes will also be studied to assess whether the statistical determinants of gait control in this population can be used as a proxy or predictor of the occurence of freezing episodes.

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Key information

Conditions

Parkinson Disease Basal Ganglia Diseases Brain Diseases Central Nervous System Diseases Movement Disorders Nervous System Diseases Neurodegenerative Diseases Parkinsonian Disorders Synucleinopathies

Age range

18 year–99 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Université catholique de Louvain

Louvain-la-Neuve, 1348, Belgium

Location status: Recruiting

Location contact

Andre Mouraux, PhD

CONTACT

[email protected]

+32 2 764 54 47

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Patients and volunteers able to walk for 20mins and without other neurological disorders.

Exclusion criteria

  • Patients or volunteers unable to walk for 20mins and with other neurological disorders.

Treatment and study plan

walking test

Other

Walk with and without a metronome

Disease assessement

Other

Disease stage assessed by a doctor

Primary outcomes

  1. Stride cadence

    Time frame: Measured during the entire experiment (an average of 4.5 years)

    Time between two consecutive heel strikes. Units are seconds.

  2. Stride amplitude

    Time frame: Measured during the entire experiment (an average of 4.5 years)

    Distance between two consecutive heel strikes. Units are meters.

Study contacts

Contact information is provided by the study sponsor or research team.

André Mouraux, PhD

CONTACT

[email protected]

+32 2 764 54 47

Frederic Crevecoeur

CONTACT

[email protected]

Sponsors and collaborators

Lead sponsor

Université Catholique de Louvain

Other

Registry information

Official study title

Flexible Control of Gait in Parkinson Disease: Effect of Task Instruction on the Exploitation of Redundancy in Speed Control.

Acronym: GAIT-PD

Important dates

Study start
2023
Primary completion
2027
Study completion
2027
First posted
Jun 18, 2023
Registry last updated
Jun 18, 2023

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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