Skip to main content
OpenTrials
Recruiting

NCT Number: NCT03071536

Furosemide Stress Test Predicting Early Graft Function in Kidney Transplantation

Furosemide is an old drug that has been used frequently in the postoperative period of kidney transplantation, aiming to achieve adequate urine output. There is no previous study that directly evaluate the urine response to standardized dose of furosemide in the postoperative period. The objective is to measure the urine output after standardized dose of furosemide is delivered, as a biomarker to predict the graft function in perioperative period.

Recruiting

Interested in participating?

Request Info

Key information

Conditions

Kidney Function Delayed Graft Function Kidney Transplant; Complications Pathologic Processes Pathological Conditions, Signs and Symptoms

Age range

18 year–80 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

King Chulalongkorn Memorial Hospital

Bangkok, 10330, Thailand

Location status: Recruiting

Location contact

Suwasin Udomkarnjananun, M.D.

CONTACT

[email protected]

66899679885

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Deceased donor kidney transplantation at KCMH
  • informed consent is accepted

Exclusion criteria

  • Known allergy to furosemide
  • Surgical complication of allograft
  • Urgently needed for dialysis (refractory hypervolemia, uremic symptoms, and hyperkalemia)

Treatment and study plan

Furosemide Injection

Drug

Furosemide 1.5 mg/kg intravenously at 3 hours post-reperfusion of kidney allograft

Primary outcomes

  1. Urine output

    Time frame: 6 hours

    Urine output per hour (milliliters/hour) after furosemide injection

Secondary outcomes

  1. Delayed graft function

    Time frame: 7 days

    Delayed graft function is defined by the necessity of dialysis within the first week after kidney transplantation. (yes/no)

  2. Creatinine reduction ratio

    Time frame: At postoperative day 0,7 and 14

    Ratio of serum creatinine at postoperative day 7 and 14 to day-zero creatinine

Study contacts

Contact information is provided by the study sponsor or research team.

Suwasin udomkarnjananun, M.D.

CONTACT

[email protected]

66899679885

Sponsors and collaborators

Lead sponsor

King Chulalongkorn Memorial Hospital

Other

Registry information

Official study title

Furosemide Stress Test as a Marker of Postoperative Kidney Allograft Function

Acronym: FOSTIK

Important dates

Study start
2016
Primary completion
2026
Study completion
2027
First posted
Mar 7, 2017
Registry last updated
Jan 17, 2024

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Related clinical trials

Published trials that share one or more normalized conditions with this study.