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Completed

NCT Number: NCT00779090

Functional Residual Capacity (FRC) Guided Alveolar Recruitment Strategy

In ventilated patients open endotracheal suctioning may lead to alveolar derecruitment, which can be monitored by means of functional residual capacity (FRC) measurements. The investigators hypothesized that a recruitment strategy based on FRC measurements would improve oxygenation and regional ventilation after an open endotracheal suctioning manoeuvre.

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Key information

Conditions

Ventilation Functional Residual Capacity Pathologic Processes Pathological Conditions, Signs and Symptoms Respiration Disorders Respiratory Aspiration Respiratory Tract Diseases

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Phase 4

About this study

In mechanically ventilated patients the functional residual capacity will be measured before (baseline) and after an open endotracheal suctioning manoeuvre. Based on these changes patients will be divided into two groups: Group A with more than 94% of baseline FRC, and Group B with less than 94% of baseline FRC. Both groups will be randomized to receive an alveolar recruitment manoeuvre or no alveolar recruitment manoeuvre, leading to four groups. Oxygenation and regional ventilation with electrical impedance tomography will be studied.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • ventilated after elective cardiac surgery

Exclusion criteria

  • hemodynamic instability (eg. intraaortic balloon pump)
  • acute lung injury, i.e. PEEP > 10cmH20 or FiO2 > 0.4

Treatment and study plan

Alveolar recruitment manoeuvre

Procedure

Increase airway pressure during pressure controlled ventilation up to peak-airway pressure of 40 cmH20 and PEEP of 15 cmH20.

Primary outcomes

  1. Arterial oxygenation

    Time frame: 60 minutes

Secondary outcomes

  1. Regional ventilation

    Time frame: 60 minutes

Sponsors and collaborators

Lead sponsor

University of Luebeck

Other

Registry information

Official study title

The Influence of a Functional Residual Capacity Guided Alveolar Recruitment Strategy After Open Endotracheal Suctioning on Oxygenation and Regional Ventilation

Important dates

Study start
2007
Primary completion
2008
Study completion
2008
First posted
Oct 24, 2008
Registry last updated
Oct 24, 2008

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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