Functional MRI for Monitoring Progression and Assessing Trends in ILD

The main objective of this study is to investigate the utility of functional MRI to differentiate, characterize, and monitor subgroups of ILD. This can be broken down into three specific objectives:

Determine if ILD features observed on high-resolution computed tomography (HRCT), such as ground glass opacities (GGO), are functionally different.

Analyse MRI metrics within each subgroup to determine whether these metrics distinguish different ILDs.

Assess MRI metrics longitudinally to see if these parameters change with disease progression, stability, or reversibility.

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Key information

Conditions

Interstitial Lung Diseases (ILD) Lung Diseases Lung Diseases, Interstitial Respiratory Tract Diseases

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Thoraxklink Heidelberg - Universitätsklinikum Heidelberg, Heidelberg, Germany

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Clinical indication for a routine HRCT because of either newly diagnosed idiopathic pulmonary fibrosis (IPF) or hypersensitivity pneumonitis (HP) or idiopathic non-specific interstitial pneumonia (iNSIP), suspected diagnosis, or follow-up
Capacity to consent
Ability to participate fully in the study (defined by the ability to lie still for the duration of imaging)

Exclusion criteria

Pregnancy and breast feeding
Persons under the age of 18 and persons not able to give informed consent
Any medical conditions that could hinder the ability to adhere to the protocol
Any MRI contraindication, including previous allergic reactions to Gd-based MRI contrast material and renal dysfunction (eGFR < 30 ml min/1,73 m2)

Treatment and study plan

Lung MRI Protocol with Functional and Contrast-Enhanced Sequences

Diagnostic Test

Participants will undergo a lung MRI protocol consisting of structural imaging, non-contrast functional imaging, and contrast-enhanced imaging. Some sequences are custom-developed and performed during free breathing to accommodate patients with respiratory limitations.

Primary outcomes

Identification of ILD Subtypes Using Baseline MRI Metrics

Time frame: Baseline (first MRI scan)

Assess whether baseline MRI metrics can accurately differentiate subtypes of interstitial lung disease, using clinician diagnosis (based on multidisciplinary discussion) as the reference standard.

Secondary outcomes

Correlation of Longitudinal MRI Changes with Disease Progression

Time frame: From enrollment (baseline MRI) through up to 1-year after enrollment; follow-up assessments will only be performed if clinically indicated.

Evaluate changes in MRI metrics over time and their correlation with ILD progression, using ATS/ERS/JRS/ALAT criteria.

Sponsors and collaborators

Lead sponsor

University Hospital Heidelberg

Other

Collaborators

German Center for Lung Research
Thoraxklinik-Heidelberg gGmbH
University Hospital Schleswig-Holstein

Registry information

Official study title

Functional Magnetic Resonance Imaging of the Lung to Detect Regional Reversibility and Progression in Interstitial Lung Disease

Acronym: IMPACT-ILD

Important dates

Study start: 2025
Primary completion: 2027
Study completion: 2027
First posted: Dec 24, 2025
Registry last updated: Dec 24, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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