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Completed

NCT Number: NCT05498532

Functional MRI Evaluation in Pyeloureteral Junction Syndrome in Children

Pyelo-ureteral junction syndrome is the most common urological abnormality in children.

Functional MRI has been evaluated several times and has shown good correlation with scintigraphy, but tends to overestimate results. Moreover, those studies included a small number of cases. Its sensitivity to detect crossing polar vessels is limited.

The investigators aimed to evaluate, in patients between 0 and 1 year old, the correlation between MRI and scintigraphy differential renal function.

The secondary objectives are the evaluation of MRI performances to detect polar vessels; the comparison of surgery times depending on MRI-only realization or MRI and scintigraphy realization.

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Key information

Conditions

Stricture of Pelviureteric Juncture

Age range

1 day–17 year

Sex eligibility

All sexes

Study type

Observational

Primary location

CHRU Nancy

Vandœuvre-lès-Nancy, Lorraine, 54 511, France

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • children between 0 and 17 years old
  • followed for pyelo-ureteral junction syndrome

Exclusion criteria

  • none

Treatment and study plan

Functional MRI

Diagnostic Test

Anatomical MRI : T2 fiesta, SSFE, HASTE ; 3D T2 ; T1 FAT SAT ; LAVA Functional MRI : T1 FAT SAT with gadolinium

Other names: Renal Scintigraphy

Primary outcomes

  1. MRI and scintigraphy differential renal function correlation

    Time frame: from january 2007 to december 2021

    Evaluation of differential renal function between MRI and scintigraphy in children between 0 and 1 year old ; Pearson correlation coefficient

Secondary outcomes

  1. MRI and scintigraphy differential renal function correlation in operated patient

    Time frame: from january 2007 to december 2021

    Evaluation of differential renal function between MRI and scintigraphy in children operated for PUJS; Pearson correlation coefficient

  2. Time difference in patient operated for PUJS depending on MRI realisation ou MRI and scintigraphy realisation

    Time frame: from january 2007 to december 2021

    Comparison between the mean time between MRI and surgery, and mean time between MRI, scintigraphy and surgery

  3. performance of MRI in detecting polar vessel

    Time frame: from january 2007 to december 2021

    Polar vessel : comparison between MRI results and operatory observation, sensitivity et specificity analysis

Sponsors and collaborators

Lead sponsor

Central Hospital, Nancy, France

Other

Registry information

Official study title

Functional MRI Usage for Pyelo-ureteral Junction Syndrome : Results of Nancy Children Hospital Cohort

Important dates

Study start
2022
Primary completion
2022
Study completion
2022
First posted
Aug 12, 2022
Registry last updated
Jun 16, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.