Functional MRI and DTI Analysis of Post VNS Therapy Rehab Changes

This study will consist of 2-3 fMRI sessions, depending on group assignment, and span 2 days for each session. It will be done at a single site only, at UTSW. The fMRI tasks will consists of subjects grasping and releasing a handgrip.

The VNS implant will be used in this study to determine if having the implant active during physical rehabilitation produces white matter tract changes in the brain visible on fMRI. All subjects in the STU 062017-071 study will receive a VNS implant. And all subjects in this study are also subjects of the STU 062017-071 study. Therefore participants of this study will enroll with the implant already in place.

Methods: After passing routine MRI screening, patients who are enrolled in the VNS-REHAB study and consent to participate in the fMRI study will be scanned on a Phillips 3 Tesla Research Magnet (Ingenia, Philips Healthcare, Best, the Netherlands). Patients will be scanned before therapy and the week after therapy. A subset of patients will be scanned 3 times, before therapy, after therapy without activation of the vagal nerve stimulator, and after therapy with activation of the vagal nerve stimulator.

Scan Time:

Scan time is limited to 15 minutes per session to match manufacture FDA guidelines. Patients will receive two, 15 minute MRI scans over 2 days.

Inclusion criteria

• This study is only including subjects from the STU 062017-071 (A Pivotal Randomized Study Assessing Vagus Nerve Stimulation (VNS) During Rehabilitation for Improved Upper Limb Motor Function After Stroke) study that choose to participate in this fMRI substudy.
• History of unilateral supratentorial ischemic stroke that occurred at least 9 months but not more than ten 10 years prior to enrollment.
• Age >22 years and <80 years.
• Fugl-Meyer Assessment-Upper Extremity (FMA-UE) score of 20 to 50 (inclusive of 20 and 50).
• Ability to communicate, understand, and give appropriate consent. Subjects should be able to follow two-step commands.
• Right- or left-sided weakness of upper extremity.
• Active wrist flexion/extension; active abduction/extension of thumb and at least two additional digits.

Exclusion criteria

• History of hemorrhagic stroke
• Presence of ongoing dysphagia or aspiration difficulties
• Subject receiving medication that may significantly interfere with the actions of VNS on neurotransmitter systems at study entry. A list of excluded medications will be provided to investigators.
• Prior injury to vagus nerve, either bilateral or unilateral (e.g. injury during carotid endarterectomy)
• Severe or worse depression (Beck Depression Scale > 29) (Beck et al., 1961)
• Unfavorable candidacy for device implant surgery (e.g. history of adverse reactions to anesthetics, poor surgical candidate in surgeon's opinion, etc)
• Current use of any other stimulation device, such as a pacemaker or other neurostimulator; current use of any other investigational device or drug
• Medical or mental instability (diagnosis of personality disorder, psychosis, or substance abuse) that would prevent subject from meeting protocol timeline
• Pregnancy or plans to become pregnant or to breastfeed during the study period
• Current or future requirement of diathermy during the study duration
• Active rehabilitation within 4 weeks prior to consent
• Botox injections or any other non-study active rehabilitation of the upper extremity within 4 weeks prior to therapy through the post-30 day visit
• Severe spasticity of the upper limb (Modified Ashworth >=3)
• Significant sensory loss. Sensory loss will be measured using the upper Extremity sensory section of the Fugl Meyer Assessment of Physical Performance. The assessment addresses light touch (2 items) and proprioception (4 items). The highest points attained is 12; subjects with scores less than 6 will be excluded from the study.