Functional Magnetic Resonance Imaging (MRI) of Hypnosis and Mindfulness Meditation

Hypnotic trance and mindfulness meditation have both been shown to have benefits for physical health. The current study seeks to determine if there are distinct patterns of brain activity that correlate with hypnotic trance, mindfulness meditation or both, and to relate these patterns to measurable markers of physical well-being. Precise neuroimaging of heightened attentional states will guide future researchers and practitioners toward more effective techniques of mind/body control.

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Key information

Conditions

Hypnosis

Sex eligibility

All sexes

Study type

Observational

Primary location

Stanford University School of Medicine

Stanford, California, 94305, United States

About this study

Our goal is to determine the functional brain networks that define and distinguish two induced states of sustained attention -- hypnosis and mindfulness -- that may be of substantial relevance to medicine.

Defining the neural underpinnings of these states would have broad implications for understanding how cognitive states emerge from functional networks, how they affect peripheral autonomic nervous system activity, and how their therapeutic efficacy can be optimized.

We propose a functional MRI study using resting state methodology to study 20-40 subjects from each of the four following groups:

Highly hypnotizable subjects
Minimally hypnotizable subjects
Experienced mindfulness meditators
Novice mindfulness meditators. The ability to be hypnotized is a stable and measurable trait that can be pre-screened and quantified. Dr. Spiegel will select subjects according to their ability to be hypnotized prior to the MRI visit (see ?recruiting? below). We will seek greatest contrast between groups by enrolling those with the highest (8-10) and lowest (0-2) scores on the Hypnotic Induction Profile. The presence of a poorly hypnotizable group allows for a control condition of those who have undergone an identical induction routine without achieving hypnotic trance. Similarly, novice meditators will serve as a control for the group experienced in mindfulness meditation.

Prior studies have shown differences in both brain activation and grey matter volume associated with longer practice of meditation (> 4 years) compared with novice meditators. As such, experienced meditators will be defined as those with a regular meditation practice of four years or longer. Novice meditators will be new practitioners who are interested in mindfulness meditation practice, and who completed a one-hour meditation training during the week before their study participation.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Participants must not have contraindications to the MRI exam, such as metal in the body.

Exclusion criteria

Contraindications to the MRI exam, such as metal in the body.
Use of psychotropic medications.

Treatment and study plan

hypnosis

Behavioral

Meditation

Behavioral

Primary outcomes

MRI scan: brain activity

Time frame: 1 hour

Sponsors and collaborators

Lead sponsor

Stanford University

Other

Registry information

Official study title

Resting State Functional MRI Investigation of Hypnotic Trance and Mindfulness Meditation

Important dates

Study start: 2009
Primary completion: 2011
Study completion: 2011
First posted: Jun 3, 2010
Registry last updated: Dec 3, 2013

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed