Functional Bioactive Supplement Effect in Lost Weight Treatment

A randomized, parallel, double-blind, controlled was performed to evaluate the therapeutic effect of a functional bioactive supplement associated with a hypocaloric equilibrated diet to treatment of obesity and overweight.

Women aged between 18 and 65 years with obesity and overweight diagnosis (IMC >25<35 kg/m2) were included in the study. The clinical trial will be performed in the Clinical Nutrition Department of La Paz University Hospital, in Madrid. All of the volunteers will receive a dietetic treatment with 1500 Kcal/day and physical activity recommendations during the study.

Inclusion criteria

• Women from 45 to 75 years old;
• Overweight (IMC ≥25<30 Kg/m2) or obese (IMC ≥30<35 Kg/m2) volunteers
• Signed informed consent.

Exclusion criteria

• Subjects with drug consumption (lipid-lowering, oral hypoglycemic agents and / or hypertensive) in less than one month period;
• Subjects with Diabetes Mellitus insulin dependent;
• Individuals that stop smoking in the next 12 weeks (during the study);
• Subjects with increased alcohol consumption (> 1 glass of vine);
• Subjects that consume drugs, vitamins, minerals, prebiotics or/and probiotics that interfere with the body's response to the extracts in the 2 weeks before to baseline;
• Subjects with drugs consumption special diet due to disease as celiac disease, chronic renal failure, etc;
• Subjects with disorders associated with eating behaviour;
• Subjects with drugs or supplements consumption to weight lost;
• Subjects with physical problems complying with the recommendations of physical activity and diet indicated;
• Subjects who refuse to perform the indicated dietary changes throughout the study;
• Subjects with diseases that could be involucrate in weight lost (not controlled hypothyroidism, serious psychiatric illness, etc.);
• Subjects with mental disease or low cognitive function;
• Subjects with severe diseases (hepatic, kidney, cancer…);
• Pregnant women or lactating;
• Subjects with physical problems complying with the recommendations of physical activity.
• Subjects with intensive physical activity;