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Active, Not Recruiting

NCT Number: NCT07702227

Functional and Physiological Responses to Multicomponent Exercise in Older Adults

This study will examine functional and physiological responses to a 12-week multicomponent exercise program in community-dwelling older adults. Adults aged 60 to 81 years will be randomly assigned to either a multicomponent exercise group or a control group. The supervised exercise program will be performed twice weekly for 12 weeks and will include aerobic walking, resistance exercises, balance and agility training, flexibility exercises, and cool-down activities. Functional performance will be assessed using the six-minute walk test, the 30-second chair stand test, and the 8-Foot Up and Go test at baseline and after 12 weeks. Resting cardiac autonomic function will be assessed using heart rate variability. In addition, an exploratory responder-non-responder analysis will be conducted to examine whether baseline heart rate variability is associated with individual functional adaptations following the exercise program. This study may help identify physiological markers related to functional responsiveness to exercise in older adults.

Active, Not Recruiting

This study is active but is not currently recruiting participants.

Key information

Conditions

Older Adults (60 - 85 Years Old) Aging Exercise Response Functional Capacity Heart Rate Variability (HRV)

Age range

60 year–81 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Canakkale Onsekiz Mart University

Çanakkale, 17100, Turkey (Türkiye)

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • being 60 years of age or older,
  • being able to walk independently,
  • not having any serious cardiovascular, neurological, or musculoskeletal disease that would prevent exercise.
  • do not use medications that may affect autonomic nervous system function

Exclusion criteria

  • diagnosed cardiac arrhythmia,
  • uncontrolled hypertension,
  • use of medications that may affect autonomic nervous system function,
  • inability to perform functional performance tests.

Treatment and study plan

Multicomponent Exercise Program

Behavioral

Participants in the exercise group will complete a supervised multicomponent exercise program twice weekly for 12 weeks. Each session will last approximately 45 to 50 minutes and include warm-up, aerobic interval walking, resistance exercises, balance and agility training, flexibility exercises, and cool-down activities. Exercise intensity will be monitored using the Borg Rating of Perceived Exertion scale and exercise difficulty will be progressively increased by increasing repetitions, walking duration, walking pace, and task complexity.

Primary outcomes

  1. Change in six-minute walk distance

    Time frame: Baseline and 12 weeks

    Functional walking capacity will be assessed using the six-minute walk test. The total distance walked in six minutes will be recorded in meters at baseline and after the 12-week intervention.

Secondary outcomes

  1. Change in 30-second chair stand test performance

    Time frame: Baseline and after 12 weeks

    Lower-limb functional strength will be assessed using the 30-second chair stand test at baseline and after the 12-week intervention.

  2. Change in 8-foot Up-and-Go test performance

    Time frame: baseline and after 12 weeks

    Functional mobility and agility will be assessed using the 8-Foot Up-and-Go test at baseline and after the 12-week intervention.

Other outcomes

  1. Change in resting heart rate variability parameters

    Time frame: Baseline to 12 weeks

    Resting heart rate variability parameters will be assessed at baseline as pre-specified exploratory physiological markers associated with individual functional responses to the exercise program.

Sponsors and collaborators

Lead sponsor

Çanakkale Onsekiz Mart University

Other

Registry information

Official study title

Functional and Physiological Responses to a 12-Week Multicomponent Exercise Program in Older Adults: An Exploratory Responder-Non-Responder Analysis

Important dates

Study start
2026
Primary completion
2026
Study completion
2026
First posted
Jul 14, 2026
Registry last updated
Jul 14, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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