fullPIERS Model in the Prediction of Adverse Maternal Outcomes in Preeclampsia

Apredictive formula, fullPIERS (Pre-eclampsia Integrated Estimate of Risk Score), can be used to estimate the risk of suffering an adverse outcome using information obtained within 48 hours of admission with pre-eclampsia. The following information is used, serum creatinine, gestational age, platelet count,

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Key information

Conditions

Preeclampsia Female Urogenital Diseases and Pregnancy Complications Fullpairs Hypertension, Pregnancy-Induced Pre-Eclampsia Pregnancy Complications Urogenital Diseases

Sex eligibility

Female

Study type

Observational

Primary location

Obsetatric and gynacological department at Sohag universtiy hospital

Sohag, Egypt

Location contact

Alaa Abdellah, Master's student

CONTACT

[email protected]

+20 01000798592

About this study

Inclusion criteria

Patients diagnosed with preeclampsia, defined by hypertension (systolic BP

≥140 mmHg and/or diastolic BP ≥90 mmHg, measured twice more than 4 hours apart after 20 weeks gestation) Proteinuria of at least 0.3 g/dl or ≥300 mg of protein in a 24-hour urine collection Urine albumin-creatinine ratio (ACR) ≥30 mg/mmol, or hypertension with end organ dysfunction after20 weeks gestation

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion Criteria Female patients diagnosed with preeclampsia. Gestational age ≥ 20 weeks.

Hypertension defined as:

Systolic blood pressure ≥ 140 mmHg and/or Diastolic blood pressure ≥ 90 mmHg, measured on at least two occasions more than 4 hours apart.

Proteinuria defined as:

300 mg protein in a 24-hour urine collection or
0.3 g/dL on urine analysis. Singleton pregnancy. Exclusion Criteria Patients who do not meet the clinical or laboratory diagnostic criteria of preeclampsia.

Treatment and study plan

Primary outcomes

Validation of the fullPIERS prediction model for adverse maternal outcomes using logistic regression-derived predicted probabilities

Time frame: 1year
Evaluate the validity of the fullPIERS model in the prediction of adverse maternal outcomes in women with pre-eclampsia in Sohag Governorate, Egypt.

Time frame: 1year

The collected data are then will be used to calculate the predicted probability of adverse outcomes using the fullPIERS logistic regression equation logit(p)=2.68+(-5.41×10-2×gestational age) +1.23×(chest pain or dyspnea)+(-2.71×10 -2×creatinine) .

Sponsors and collaborators

Lead sponsor

Sohag University

Other

Registry information

Official study title

A Prospective Study of Validation of the fullPIERS Model in the Prediction of Adverse Maternal Outcomes in Women With Pre- Eclampsia in Sohag University Hospital

Acronym: Aprospective

Important dates

Study start: 2026
Primary completion: 2026
Study completion: 2026
First posted: Jan 5, 2026
Registry last updated: Jan 5, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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