FTO Gene Variants and Diet in Obesity

Studies have shown that the effect of fat mass and obesity-associated (FTO) gene on obesity is modulated by lifestyle factors. Hence, we aimed to determine whether two single nucleotide polymorphisms (SNPs) in the FTO gene are associated with obesity and to assess whether these associations were modified by lifestyle factors. The study included 200 obese and 200 non-obese individuals from Turkey. Our study suggests that the effect of the SNPs on obesity traits is likely to be influenced by lifestyle factors in this Turkish population.

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Key information

Conditions

Obesity Behavior Behavior, Animal Body Weight Diet Habit Disease Attributes Disease Susceptibility Feeding Behavior Genetic Predisposition Genetic Predisposition to Disease Nutrition Disorders Nutritional and Metabolic Diseases Overnutrition Overweight Pathologic Processes Pathological Conditions, Signs and Symptoms Signs and Symptoms

Age range

24 year–50 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Zehra Buyuktuncer

Ankara, 06100, Turkey (Türkiye)

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

attending routine outpatient visits,
aged 24 to 50 years,
having a BMI ≥ 18.50 kg/m2

Treatment and study plan

Primary outcomes

Genetic analysis of two SNPs at FTO gene

Time frame: up to 36 weeks

FTO SNPs rs9939609 and rs10163409
Anthropometric measurements

Time frame: up to 36 weeks

Body mass index, waist circumference, hip circumference, body composition
Biochemical measurements

Time frame: up to 36 weeks

lipid profile, glucose, insulin, adiponectin

Sponsors and collaborators

Lead sponsor

Hacettepe University

Other

Collaborators

The Scientific and Technological Research Council of Turkey
University of Reading

Registry information

Official study title

Impact of FTO Gene Variants and Lifestyle Factors on Obesity Traits in a Turkish Population

Important dates

Study start: 2017
Primary completion: 2018
Study completion: 2018
First posted: Dec 19, 2019
Registry last updated: Dec 19, 2019

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed