Fructose Extra-splanchnic Metabolism and Its Effects on Systemic Flux of Substrates (FruPP)

In parallel to the dramatic rise in metabolic diseases and diabetes observed over the past fifty years, the generalization of added sugar in processed food led to a marked increase in fructose consumption in almost all countries, and epidemiological studies demonstrated that the consumption of sugar-sweetened beverage (containing at least 50% of fructose) is associated with the development of diabetes, hepatic steatosis, dyslipidemia and obesity.

The objective of the study is to measure the amount of fructose that escape first-pass hepatic extraction after oral ingestion (fructose+glucose), and gain insights into its metabolic fates with the use of tracers.

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Key information

Conditions

Test Meal Body Weight Nutrition Disorders Nutritional and Metabolic Diseases Obesity Overnutrition Overweight Pathological Conditions, Signs and Symptoms Signs and Symptoms

Age range

18 year–40 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

University of Lausanne

Lausanne, 1005, Switzerland

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Aged from 18 to 40 years
Body Mass Index of 18.5 to 25 kg/m²
Sex male of female

Exclusion criteria

Fructose intolerance
Antidiabetic and hypolipemic drugs
Alcohol consumption >10g/day
Severe eating disorders
Severe psychological problems
Vegetarian diet or other specific diet
Consumption of illicit substances
Pregnancy
Weight gain or weight loss > 3 kg in the last 3 months

Treatment and study plan

Test meal

Other

Liquid test meal (fructose+glucose)

Primary outcomes

Measurement of the amount of fructose that escape first-pass hepatic extraction after oral ingestion.

Time frame: The quantity of 13C fructose will be calculated, during the post prandial period, until 240 min.

Calculation with 13C fructose enrichment in blood samples at T0; 30; 60; 90; 120; 150; 180; 210 and 240 min.

Sponsors and collaborators

Lead sponsor

University of Lausanne

Other

Registry information

Acronym: FruPP

Important dates

Study start: 2017
Primary completion: 2018
Study completion: 2018
First posted: Jun 22, 2017
Registry last updated: Oct 18, 2018

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed