John Radcliffe Hospital
Oxford, OX39DU, United Kingdom
Location status: Recruiting
NCT Number: NCT06485986
The goal of this experimental study with is to understand the underlying mechanisms behind the increase in impulsivity seen in some patients that undergo deep brain stimulation of the subthalamic nucleus for Parkinson's Disease. The main questions it aims to answer are:
What are the distributed network effects of deep brain stimulation to the subthalamic nucleus? How does this correlate with increased impulsivity? Can alternative stimulation settings be used to minimize these?
Participants will complete decision-making tasks whilst their deep brain stimulation devices are turned on and off with simultaneous magnetoencephalography recordings (a type of non-invasive brain scan that measures brain activity in real-time)
Interested in participating?
Request Info18 year and older
All sexes
Interventional
Not applicable
Oxford, OX39DU, United Kingdom
Location status: Recruiting
Healthy volunteers accepted: No
Only the study team can determine whether someone qualifies for participation.
Inclusion criteria
Exclusion criteria
DBS will be turned on and off for experimental periods to compare the effect of DBS on behaviour.
Time frame: 12 months
Correlation between response time and accuracy with electrophysiological signatures of neural activity.
Contact information is provided by the study sponsor or research team.
University of Oxford
Other
Frontosubthalamic Network Dynamics and Their Modulation During Impulse Control and Decision Making in Parkinson's Disease
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