Superhumans War Trauma Center
Lviv, Ukraine
NCT Number: NCT07474506
To compare the effectiveness of continuous regional anaesthesia with standard pain management strategies for the treatment of acute pain in patients with war-related lower limb trauma.
Trial opening soon.
Get Notified18 year–50 year
All sexes
Observational
Lviv, Ukraine
War-related lower limb trauma represents one of the most frequent and severe injury patterns in modern armed conflicts. Blast injuries, gunshot wounds, and complex soft-tissue damage often result in severe acute pain requiring repeated surgical procedures, prolonged hospitalization, and intensive rehabilitation.
Adequate pain management in this population is critical not only for immediate patient comfort but also for facilitating wound care, early mobilization, rehabilitation participation, and potentially reducing the risk of long-term pain syndromes.
Continuous regional anaesthesia (CRA), delivered through ultrasound-guided peripheral nerve catheters, allows prolonged targeted analgesia by continuous infusion of local anesthetics. Compared with systemic analgesia or single-shot regional blocks, CRA may provide superior and sustained pain control, reduce opioid exposure, and improve rehabilitation tolerance.
However, evidence regarding the effectiveness of continuous regional anaesthesia in war-related lower limb trauma remains limited, particularly in real-world trauma settings involving blast injuries and multi-stage reconstructive surgery.
This study aims to evaluate the effectiveness and safety of continuous regional anaesthesia compared with standard analgesic strategies in patients with war-related lower limb trauma.
Healthy volunteers accepted: No
Only the study team can determine whether someone qualifies for participation.
Inclusion criteria
Exclusion criteria
Time frame: Pain intensity will be assessed at 6, 12, 24, 48, and 72 hours after initiation of analgesia.
Pain scores will be recorded:
at rest during movement during wound care or dressing changes.
Time frame: Cumulative opioid consumption during the first 72 hours after initiation of analgesic therapy.
Total opioid consumption will be recorded during the first 72 hours after initiation of analgesic treatment. All administered opioids will be converted to morphine milligram equivalents (MME) using standard opioid conversion factors to allow comparison between treatment groups. The cumulative opioid dose will be calculated for each patient and analyzed as a measure of opioid requirement during the acute post-traumatic period.
Contact information is provided by the study sponsor or research team.
Charitable Organisation Charitable Fund Superhumans (Co Cf Superhumans)
Other
From Battlefield to Recovery: Continuous Regional Anaesthesia for War-Related Lower Limb Trauma - A Multicenter Comparative Cohort Study
Acronym: CRA-WAR-LIMB S
OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.
View the official ClinicalTrials.gov record (opens in a new tab)This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.
Published trials that share one or more normalized conditions with this study.
NCT06968546
Acute Pain, Agnosia
Nice, France
View Trial DetailsNCT07254923
Acute Pain, Agnosia
Chiquinquirá, Departamento de Boyacá, Colombia
View Trial DetailsNCT07335159
Acute Pain, Agnosia
Tallahassee, Florida, United States
View Trial DetailsNCT07562412
Acute Pain, Agnosia
Tallahassee, Florida, United States
View Trial Details