Skip to main content
OpenTrials
Not Yet Recruiting

NCT Number: NCT07474506

From Battlefield to Recovery: Continuous Regional Anaesthesia for War-Related Lower Limb Trauma

To compare the effectiveness of continuous regional anaesthesia with standard pain management strategies for the treatment of acute pain in patients with war-related lower limb trauma.

Not Yet Recruiting

Trial opening soon.

Get Notified

Key information

About this study

War-related lower limb trauma represents one of the most frequent and severe injury patterns in modern armed conflicts. Blast injuries, gunshot wounds, and complex soft-tissue damage often result in severe acute pain requiring repeated surgical procedures, prolonged hospitalization, and intensive rehabilitation.

Adequate pain management in this population is critical not only for immediate patient comfort but also for facilitating wound care, early mobilization, rehabilitation participation, and potentially reducing the risk of long-term pain syndromes.

Continuous regional anaesthesia (CRA), delivered through ultrasound-guided peripheral nerve catheters, allows prolonged targeted analgesia by continuous infusion of local anesthetics. Compared with systemic analgesia or single-shot regional blocks, CRA may provide superior and sustained pain control, reduce opioid exposure, and improve rehabilitation tolerance.

However, evidence regarding the effectiveness of continuous regional anaesthesia in war-related lower limb trauma remains limited, particularly in real-world trauma settings involving blast injuries and multi-stage reconstructive surgery.

This study aims to evaluate the effectiveness and safety of continuous regional anaesthesia compared with standard analgesic strategies in patients with war-related lower limb trauma.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • age ≥18 years
  • war-related lower limb trauma
  • hospital admission requiring surgical treatment or wound management
  • documented pain assessment during hospitalization
  • availability of analgesic treatment data
  • informed consent where required

Exclusion criteria

  • age <18 years
  • isolated upper limb trauma
  • missing key pain outcome data
  • contraindication to regional anaesthesia prior to treatment
  • refusal to participate (for prospective component)

Treatment and study plan

Primary outcomes

  1. Pain intensity measured by Numeric Rating Scale (NRS 0-10) during the first 72 hours after initiation of analgesic treatment.

    Time frame: Pain intensity will be assessed at 6, 12, 24, 48, and 72 hours after initiation of analgesia.

    Pain scores will be recorded:

    at rest during movement during wound care or dressing changes.

Secondary outcomes

  1. Total opioid consumption during first 72 hours, expressed as morphine milligram equivalents (MME).

    Time frame: Cumulative opioid consumption during the first 72 hours after initiation of analgesic therapy.

    Total opioid consumption will be recorded during the first 72 hours after initiation of analgesic treatment. All administered opioids will be converted to morphine milligram equivalents (MME) using standard opioid conversion factors to allow comparison between treatment groups. The cumulative opioid dose will be calculated for each patient and analyzed as a measure of opioid requirement during the acute post-traumatic period.

Study contacts

Contact information is provided by the study sponsor or research team.

Dmytro Dmitriy Dmytriiev, PhD.Professor

CONTACT

[email protected]

+380674309449

Sponsors and collaborators

Lead sponsor

Charitable Organisation Charitable Fund Superhumans (Co Cf Superhumans)

Other

Registry information

Official study title

From Battlefield to Recovery: Continuous Regional Anaesthesia for War-Related Lower Limb Trauma - A Multicenter Comparative Cohort Study

Acronym: CRA-WAR-LIMB S

Important dates

Study start
2026
Primary completion
2026
Study completion
2026
First posted
Mar 16, 2026
Registry last updated
Mar 17, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.