Completed

NCT Number: NCT07600060

Frequency of Platelets Transfusion & Post-Operative Bleeding Risk in Patients on Clopidogrel Undergoing CABG

The goal of this retrospective cohort study Is to Primarily be platelet transfusion frequency and postoperative bleeding risk, analysis using descriptive and inferential statistics in all eligible patients admitted to the cardiac intensive care unit (CICU) for open-heart surgery were included of both gender, age group of 30-80 years. The main questions it aims to answer are:

* How was the frequency of platelet transfusion during the index admission evaluated? * How was post-operative bleeding risk measured? * What does 24-hour chest drain output indicate in this context? * How was packed cell volume (PCV) transfusion used as an outcome measure?

Completed

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Key information

Conditions

Patients on Clopidogrel Platelets Transfusion

Age range

30 year–80 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Aga khan University

Karachi, Sindh, 7480 0, Pakistan

About this study

The Cardiac Intensive Care Unit (CICU) at a tertiary care facility in Karachi, Pakistan, served as the site of this retrospective cohort study. Every procedure adhered to institutional policies, and safe data management and de-identification preserved confidentiality. Consecutive sampling was employed due to the retrospective methodology, and the sample included all eligible CICU patients who had heart surgery during the study period. The study included patients on dual antiplatelet treatment (DAPT: aspirin and/or clopidogrel) with the last dose within five days before to surgery, as well as adults between the ages of thirty and eighty undergoing heart surgery with cardiopulmonary bypass (CPB).

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

CICU patients who underwent cardiac surgery
Adults aged 30-80 years undergoing cardiac surgery with cardiopulmonary bypass
Patients who received dual antiplatelet therapy, last dose within 5 days before surgery

Exclusion criteria

BMI > 40 kg/m²
Repeat open-heart surgery (reoperation)
Transferred open-chest procedures
Active liver disease
Chronic lung disease
Dialysis dependence
Intra-aortic balloon pump (IABP) in place pre- or post-operatively
Major neurological deficit within the past 6 months
Incomplete clinical records

Treatment and study plan

Primary outcomes

Frequency of platelet transfusion

Time frame: From the day 1 of admission till discharge or 30 days of admission

The frequency of platelet transfusion during the hospital stay.

Other outcomes

Time to re-intubation

Time frame: 30-60 seconds from laryngoscope insertion in the oral cavity tilldetection of end tidal carbon dioxide trace.

The number of times reintubation occurred, i.e. the endotracheal tube was reinserted.

Sponsors and collaborators

Lead sponsor

Aga Khan University

Other

Registry information

Official study title

Frequency of Platelets Transfusion and Post-Operative Bleeding Risk in Patients on Clopidogrel Undergoing Coronary Artery Bypass Grafting (CABG): A Retrospective Cohort

Important dates

Study start: 2022
Primary completion: 2023
Study completion: 2023
First posted: May 20, 2026
Registry last updated: May 20, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.