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NCT Number: NCT07159867

Frequency of Hypermobility-Related Problems in Patients With Anorexia Nervosa

The purpose of this study is to examine the frequense of generalized hypermobility and pain in patients with Anorexia Nervosa. The study further explores two main questions: (1) whether generalized hypermobility may be an explanatory factor for pain in some patients with Anorexia Nervosa, and (2) whether temporomandibular joint problems (such as instability, pain, difficulties opening the mouth, locking, or clicking) contribute to eating difficulties in certain individuals with Anorexia Nervosa.

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Key information

Conditions

Anorexia Nervosa, Atypical Anorexia Nervosa Feeding and Eating Disorders Joint Diseases Joint Instability Mental Disorders Musculoskeletal Diseases Neurologic Manifestations Pain Pathological Conditions, Signs and Symptoms Signs and Symptoms

Age range

13 year–25 year

Sex eligibility

Female

Study type

Observational

Primary location

Queen Silvias Children´s Hospital

Gothenburg, Västra Götaland County, 416 50, Sweden

About this study

Patients with eating disorder diagnosis Anorexia Nervosa, who are either currently in treatment or awaiting treatment at the Eating Disorders Center for children and young adults in Gothenburg, will be invited to participate in the study. During a single examination session, the patient's joints will be assessed to determine whether generalized hypermobility is present. At the same visit, the patient will answer questions regarding possible bodily pain and any temporomandibular joint problems. Joint mobility will be examined and assessed by a physiotherapist at the clinic. The examination follows a standardized protocol for assessing joint mobility and includes the assessment of nine specified joints.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Female patients Aged 13-25 years

Diagnosed with:

  • Anorexia Nervosa (ICD-10 F50.0), or
  • Atypical Anorexia Nervosa (ICD-10 F50.1)
  • Currently receiving treatment or scheduled to receive treatment

Exclusion criteria

  • Severe cognitive impairment
  • Insufficient Swedish language skills that make it impossible to provide informed consent and prevent answering study questions
  • Pregnancy and up to one year postpartum

Treatment and study plan

Primary outcomes

  1. Joint hypermobility

    Time frame: One-time assessment at baseline (Day 0, at the inclusion visit).

    Joint mobility will be assessed according to the Beighton score using a goniometer.

  2. 5-part questionnaire

    Time frame: One-time questionnaire at baseline (Day 0, after clinical examination).

    Participants over the age of 18 will also complete the 5-part questionnaire regarding historical hypermobility.

Secondary outcomes

  1. Joint pain

    Time frame: One-time questionnaire at baseline (Day 0, after clinical examination).

    The Numeric Rating Scale (NRS) is a self-assessment tool used to describe the patient's perceived pain intensity. The patient marks the intensity on a line with eleven points, ranging from 0 to 10. The endpoints represent 0 = 'no pain' and 10 = 'worst imaginable pain.'

  2. Temporomandibular joint problems

    Time frame: One-time questionnaire at baseline (Day 0, after clinical examination).

    Screening questions regarding temporomandibular joint problems. The short version of the Diagnostic Criteria for Temporomandibular Disorders (DC/TMD) classification system will be used.

  3. Pain drawing

    Time frame: One-time questionnaire at baseline (Day 0, after clinical examination).

    Participant marks areas of perceived pain on a schematic human body figure.

Study contacts

Contact information is provided by the study sponsor or research team.

Elke Schubert Hjalmarsson, PhD

CONTACT

[email protected]

+46700824535

Sponsors and collaborators

Lead sponsor

Vastra Gotaland Region

Other Gov

Registry information

Important dates

Study start
2025
Primary completion
2026
Study completion
2026
First posted
Sep 8, 2025
Registry last updated
Sep 8, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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