Frequency of Diagnostic Symptomatic Pulmonary Embolism's in Patients Hospitalized for Clinical Exacerbation of Chronic Obstructive Pulmonary Disease (COPD)

A standardized diagnostic strategy of pulmonary embolism will be applied to eligible patients, incorporating a clinical probability score (revised Geneva score), plasma D-dimer assay and if necessary, a multidetector-row CT angiography thoracic and venous ultrasound of the lower limbs. All the patient with a pulmonary embolism diagnosed or not, will be followed for 3 months.

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Key information

Conditions

Chronic Obstructive Pulmonary Disease Cardiovascular Diseases Chronic Disease Disease Attributes Embolism Embolism and Thrombosis Lung Diseases Lung Diseases, Obstructive Pathologic Processes Pathological Conditions, Signs and Symptoms Patients Hospitalized for a COPD Exacerbation Pulmonary Disease, Chronic Obstructive Pulmonary Embolism Respiratory Tract Diseases Vascular Diseases

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

CHU, Angers, France

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Patients hospitalized for a COPD exacerbation
COPD previously diagnosed

Exclusion criteria

Allergy to iodinated contrast
Creatinine clearance < 30 mL / min
Patient hospitalized for exacerbation of COPD for more than 48 hours
Pneumothorax
Exams impossible to be performed
Pregnancy
Life expectancy < 3 months
Patients already receiving anticoagulant therapy for another reason (mechanical valve, cardiac arrhythmia).

Treatment and study plan

PEP

Other

Other names: No drug and no placebo were used in this study. For all the patients who participated at the study PEP, only exams must be performed;

Primary outcomes

Frequency of pulmonary embolism in patients hospitalized for a clinical exacerbation of COPD.

Time frame: 27 months

Secondary outcomes

The rate of pulmonary embolism diagnosed during the 3 month follow-up in patients whom pulmonary embolism was initially excluded when they've been included in the study

Time frame: 27 months

Sponsors and collaborators

Lead sponsor

University Hospital, Brest

Other

Registry information

Acronym: PEP

Important dates

Study start: 2014
Primary completion: 2017
Study completion: 2017
First posted: Jan 14, 2014
Registry last updated: Dec 3, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

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