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NCT Number: NCT03272724

French National Observatory on Infective Endocarditis

The objective of this observatory is to provide a national database of infective endocarditis, informed by all volunteer centers, using a standardized case report forms.

Such an observatory will describe the clinical profile, microbiological, therapeutic and evolving of infective endocarditis (IE); analyze the risk factors for the disease and its prognosis factors of evolution; describe management practices; evaluate and compare in the real drug treatment strategies (including antibiotics) and surgical.

Recruiting

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Key information

Conditions

Infective Endocarditis Cardiovascular Diseases Endocarditis Heart Diseases

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

CHRU

Vandœuvre-lès-Nancy, 54511, France

Location status: Recruiting

Location contact

Christine SELTON-SUTY, MD

CONTACT

[email protected]

About this study

All the clinical, biological, microbiological and laboratory describing the history of patients and their evolution during hospitalization for infective endocarditis will be obtained from physicians supporting patients and recorded in an electronic case report form. Will include collected clinical characteristics (site, pre-existing heart disease underlying symptoms, complications), biological characteristics (dosage on admission and diagnosis), microbiological characteristics (identifying the genus and species of the microorganism responsible, sensitivity to antibiotics susceptibility testing and evaluated by determination of minimal inhibiting concentration (MIC), exhaustive search of the rare forms of endocarditis uncultivated microorganisms), an analysis of the gateways based on the causative organism; echocardiographic characteristics (number and size of vegetations, valvular damage, scalable: surgery, lethality) and therapeutic characteristics (antibiotic treatment, surgical).

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Major Patient
  • Supported in one of the participating centers
  • The application of diagnostic classification criteria of Duke modified by Li is carried out after collection of all the data at the end of the patient's hospitalization. Only patients meeting criteria for definite or possible endocarditis will be included in the analyses.
  • Registered with the French social security system

Exclusion criteria

  • Refusal of the patient to participate.

Treatment and study plan

Primary outcomes

  1. history of heart disease

    Time frame: inclusion

    status of heart valves, pre-existing heart conditions

  2. risk factors, medical history

    Time frame: inclusion

    associated diseases

  3. origin of infection

    Time frame: period of 3 months before infective endocarditis

    high risk procedures

  4. weight

    Time frame: inclusion

    kg

  5. height

    Time frame: inclusion

    cm

  6. clinical symptoms

    Time frame: inclusion

    cardiac, peripheral and neurological symptoms

  7. biological outcomes

    Time frame: inclusion

    blood count

  8. microbiological outcomes

    Time frame: inclusion

    identification of infecting organisms

  9. diagnostic imaging

    Time frame: inclusion

    description of tyhe imaging tests performed

  10. antibiotic therapy

    Time frame: from inclusion to recovery

    antibiotic treatment: type and duration

  11. surgical procedures

    Time frame: from inclusion to recovery

    description of surgical procedures

Secondary outcomes

  1. biologic collection (optional)

    Time frame: inclusion

    plasma and serum collection

Study contacts

Contact information is provided by the study sponsor or research team.

Nadine JUGE, PhD

CONTACT

[email protected]

Sponsors and collaborators

Lead sponsor

Central Hospital, Nancy, France

Other

Collaborators

  • Beaujon Hospital
  • Beziers Hospital
  • Bicetre Hospital
  • Bichat Hospital
  • Centre Cardiologique du Nord
  • Centre Hospitalier Annecy Genevois
  • Centre Hospitalier Argenteuil
  • Centre Hospitalier Intercommunal Robert Ballanger
  • Centre Hospitalier Intercommunal Villeneuve Saint Georges
  • Centre Hospitalier Régional Metz-Thionville
  • Centre Hospitalier Régional d'Orléans
  • Centre Hospitalier Universitaire Dijon
  • Centre Hospitalier Universitaire de Besancon
  • Centre Hospitalier Universitaire de Nīmes
  • Centre Hospitalier Universitaire de Saint Etienne
  • Centre Hospitalier Universitaire de la Guadeloupe
  • Centre Hospitalier Universitaire, Amiens
  • Centre Hospitalier d'Alès-Cévennes
  • Centre Hospitalier de Roanne
  • Centre hospitalier Pierre Oudot Bourgoin-Jallieu
  • Centre hospitalier de Chambéry
  • Centre hospitalier de Saint Dié des Vosges
  • Centre hospitalier de Vannes
  • Chalons en Champagne hospital
  • Clinique Saint Vincent Epernay
  • Clinique du Millenaire
  • Epernay hospital
  • European Georges Pompidou Hospital
  • Fondation Hôpital Saint-Joseph
  • HIA Begin, Saint Mandé
  • Henri Mondor University Hospital
  • Hopital Foch
  • Hopital Lariboisière
  • Hopital Nord Franche-Comte
  • Hopital Universitaire Robert-Debre
  • Hospices Civils de Lyon
  • Hospital Avicenne
  • Hospital St. Joseph, Marseille, France
  • Hotel Dieu Hospital
  • Hôpital Cochin
  • Hôpital Jean Verdier
  • Hôpital Maison Blanche Reims
  • Hôpital Necker-Enfants Malades
  • Hôpital Saint André, Reims
  • Hôpital d'Instruction des Armées Desgenettes
  • Hôpital d'Instruction des Armées Legouest
  • Hôpital intercommunal Sud Léman Valserine, Saint Julien en Genevois
  • Hôpital sainte Blandine Metz
  • Hôpital-clinique Claude Bernard, Metz
  • L'hôpital Nord-Ouest - Villefranche Villefranche sur Saône
  • Lons le Saunier hospital
  • Louis Pasteur hospital, Bagnols sur Cèze
  • Narbonne Hospital
  • Perpignan Hospital Center
  • Pitié-Salpêtrière Hospital
  • Poitiers University Hospital
  • Polyclinique Courlancy, Reims
  • Polyclinique Louis Pasteur Essey-les-Nancy
  • Pontarlier hospital
  • Raincy Montfermeil Hospital Group
  • Rennes University Hospital
  • Saint Antoine University Hospital
  • Saint Malo hospital
  • Saint-Louis Hospital, Paris, France
  • Tenon Hospital, Paris
  • University Hospital, Bordeaux
  • University Hospital, Grenoble
  • University Hospital, Montpellier
  • University Hospital, Strasbourg, France

Registry information

Acronym: ObservatoireEI

Important dates

Study start
1991
Primary completion
2026
Study completion
2027
First posted
Sep 6, 2017
Registry last updated
Sep 23, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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