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Completed

NCT Number: NCT05793229

Frailty Trajectories and Their Association With Health Outcomes

Frailty is common in gastric cancer survivors and seriously affects their prognosis. Multiple longitudinal follow-up assessment of frailty could provide a better understanding of the frailty change of individuals. Our aims were to identify the longitudinal trajectories of frailty and estimate their association with health outcomes in elderly gastric cancer survivors.

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Key information

Conditions

Frailty Syndrome Frailty Pathologic Processes Pathological Conditions, Signs and Symptoms

Age range

60 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Xueyi Miao

Nanjing, Jiangsu, 211166, China

About this study

Our study suggested the significant heterogeneity in frailty trajectories among elderly gastric cancer survivors, and that different trajectories had different effects on health outcomes. Our results infer the necessity for prevention strategies in elderly gastric cancer survivors to manage heterogeneous frailty trajectories.

Who can participate

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • diagnosed with gastric cancer by endoscopy or pathology;
  • received radical gastrectomy the first time;
  • aged ≥60 years;
  • been able to communicate simply in writing and verbal;
  • completed the data collection of all follow-up points.

Exclusion criteria

  • received radiotherapy or chemotherapy before surgery;
  • had other sites of malignant tumors;
  • complicated with severe heart, liver, lung and renal insufficiency;
  • had physical disability.

Treatment and study plan

observation

Other

observation

Primary outcomes

  1. quality of life (QOL)

    Time frame: at 1-year after surgery

    used EORTC QLQ-STO22 to assess.

  2. disability

    Time frame: at 1-year after surgery

    used Elderly Disability Assessment Scale to assess.

  3. 1-year hospital readmissions

    Time frame: at 1-year after surgery

    captured from medical records.

  4. total costs

    Time frame: at 1-year after surgery

    captured from medical records.

Sponsors and collaborators

Lead sponsor

Nanjing Medical University

Other

Registry information

Official study title

Exploration of Frailty Trajectories and Their Association With Health Outcomes in Elderly Gastric Cancer Survivors Undergoing Radical Gastrectomy: a Prospective Longitudinal Observation Study

Important dates

Study start
2021
Primary completion
2021
Study completion
2023
First posted
Mar 31, 2023
Registry last updated
Mar 31, 2023

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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