Frailty, Hip Fractures and Inflammatory Biomarkers

We ought to investigate if hip fracture patients suffering from frailty have higher inflammatory burden according to simple inflammatory biomarkers.

Recruiting

Interested in participating?

Request Info

Key information

Conditions

Frailty Femoral Fractures Fractures, Bone Hip Fracture Hip Fractures Hip Injuries Inflammatory Biomarkers Leg Injuries Pathologic Processes Pathological Conditions, Signs and Symptoms Wounds and Injuries

Age range

65 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Larissa University Hospital, Larissa, Thessaly, Greece

About this study

Frailty (F) is a prevalent syndrome among elderly patient with hip fractures (HF) and has been linked to poor prognosis. Inflammatory biomarkers have been used as prognostic indexes in patients with HF. We ought to investigate if hip fracture patients suffering from frailty have higher inflammatory burden according to simple inflammatory biomarkers.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

age &gt;65 years, ASA PS I-III, non- institutionalized, able to communicate patients

Exclusion criteria

Patients with severe cognitive dysfunction, those treated conservatively, those with pathological fractures and patients who refused to participate

Treatment and study plan

Primary outcomes

Frailty status

Time frame: preoperatively

Frailty will be categorized based on the validated Groningen Frailty Indicator (GFI) as non-frail (NF, score 0,1), pre-frail (PF, score 2, 3) and severe frail (SF, score >4).
Inflammatory biomarkers

Time frame: preoperatively

Upon admission and immediate before surgery upper limits of white blood cells (WBC) within normal range (WBC >8 10^3/μL), NLR (neutrophils/lymphocytes), PLR (platelets/lymphocytes), CRP (C-reactive protein) and CLR (CRP/lymphocytes), will be recorded.

Study contacts

Contact information is provided by the study sponsor or research team.

Eleni Arnaoutoglou, Professor

CONTACT

[email protected]

+302413502952

Maria Ntalouka, MD, PhD, MSc

CONTACT

Sponsors and collaborators

Lead sponsor

University of Thessaly

Other

Registry information

Official study title

Frailty in Hip Fracture Patients Treated With Surgery; the Role of Simple Inflammatory Biomarkers. An Observational Study

Important dates

Study start: 2023
Primary completion: 2027
Study completion: 2027
First posted: Sep 26, 2024
Registry last updated: May 5, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Recruiting