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Completed

NCT Number: NCT07621276

Frailty and Severity as Determinants of Hospital Cost in the ICU

This study evaluated the association between baseline frailty (mFI-11) and acute illness severity (SAPS 3) with real hospital costs in adult patients admitted to the Intensive Care Unit (ICU). The objective was to determine if frailty and severity are independent predictors of resource consumption.

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Key information

Conditions

Frailty Critical Illness Disease Attributes Hospital Costs Pathologic Processes Pathological Conditions, Signs and Symptoms

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Hospital H+ Querétaro, Santiago de Querétaro, Querétaro

Querétaro City, Querétaro, 7600, Mexico

About this study

A retrospective cohort study was conducted at Hospital H+ Querétaro involving 142 adult patients admitted to the ICU between January 2024 and May 2025. Baseline frailty was calculated using the 11-item Modified Frailty Index (mFI-11), and acute severity was assessed with the SAPS 3 score. Total hospital costs were obtained from institutional financial records. Multivariate models were used to adjust for comorbidities (Charlson Index) and other clinical variables to identify independent determinants of hospital expenditure.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Patients aged 18 years or older.
  • Admission to the ICU between January 1, 2024, and May 31, 2025.
  • Complete medical records allowing for the calculation of mFI-11, SAPS 3, and Charlson Index.
  • Availability of institutional records regarding actual hospital costs.Exclusion Criteria:
  • Incomplete records for primary exposure or outcome variables.
  • Patients transferred from other institutions without sufficient baseline data.
  • Severe inconsistencies in cost records.
  • Subsequent readmissions where costs cannot be independently attributed to the index episode.

Treatment and study plan

Total Real Hospital Cost.

Other

The total monetary expenditure (expressed in Mexican Pesos) generated during the hospital stay, as recorded in the institutional financial database.

Primary outcomes

  1. Total Real Hospital Cost

    Time frame: From ICU admission to hospital discharge (approximately 17 months of data collection period).

    The total monetary expenditure (in local currency) recorded in the institutional administrative database for the hospital episode, from admission to discharge or death.

Sponsors and collaborators

Lead sponsor

Hospital H+ Queretaro

Other

Registry information

Official study title

Frailty and Severity as Determinants of Hospital Cost in the Intensive Care Unit: A Retrospective Cohort Study With Partial Economic Evaluation.

Acronym: FRESH-ICU

Important dates

Study start
2024
Primary completion
2025
Study completion
2025
First posted
Jun 2, 2026
Registry last updated
Jun 17, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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