Fractional Flow Reserve Guided Immediate Versus Staged Complete Myocardial Revascularization in Patients With ST-segment Elevation Myocardial Infarction With Multivessel Disease (Future Study)

Objectives: The purpose of this study is to investigate whether FFR guided PCI strategy for non-culprit lesions should be attempted during the index procedure or staged in ST-segment-elevation myocardial infarction patients with multivessel coronary disease.

Inclusion criteria

• Age ≥ 18 years
• Patients presenting STEMI and multivessel coronary disease successful primary PCI of the culprit lesion (including those who still have ischemic symptoms within 48 hours)
• Multivessel disease was defined at least one non-culprit coronary arteries with a diameter of 2.5 mm or more and a maximum diameter at least 50% stenosis by visual estimation, PCI can be successfully implemented
• Sign an informed consent form before participating in the study

Exclusion criteria

• Received thrombolytic therapy
• Cardiac shock or SBP<90mmHg;
• History of old myocardial infarction;
• Left main artery lesion, non infarct related vessels are CTO lesions;
• PCI in the previous 30 days or Previous CABG
• Patients who cannot give informed consent or have a life expectancy of less than 1 year
• Patients combined with other serious diseases such as severe renal dysfunction (creatinine clearance value<30ml/min;), liver dysfunction and thrombocytopenia
• Patients with severe valve disease, hypertrophic cardiomyopathy, restrictive cardiomyopathy, and primary pulmonary hypertension;
• Not suitable for clinical research:

• . Currently participating in another study that may affect the primary endpoint
• . Pregnant and lactating women;
• . Known allergy to drugs that may be used in the study;
• . Unable to comply with the trial protocol or follow-up requirements; Or the researcher believes that participating in the trial may result in patients facing greater risks.

Inclusion criteria

• Age ≥ 18 years
• Patients presenting STEMI and multivessel coronary disease successful primary PCI of the culprit lesion (including those who still have ischemic symptoms within 48 hours)
• Multivessel disease was defined at least one non-culprit coronary arteries with a diameter of 2.5 mm or more and a maximum diameter at least 50% stenosis by visual estimation, PCI can be successfully implemented
• Sign an informed consent form before participating in the study

Exclusion criteria

• Received thrombolytic therapy
• Cardiac shock or SBP<90mmHg;
• History of old myocardial infarction;
• Left main artery lesion, non infarct related vessels are CTO lesions;
• PCI in the previous 30 days or Previous CABG
• Patients who cannot give informed consent or have a life expectancy of less than 1 year
• Patients combined with other serious diseases such as severe renal dysfunction (creatinine clearance value<30ml/min;), liver dysfunction and thrombocytopenia
• Patients with severe valve disease, hypertrophic cardiomyopathy, restrictive cardiomyopathy, and primary pulmonary hypertension;
• Not suitable for clinical research:

• Currently participating in another study that may affect the primary endpoint
• Pregnant and lactating women;
• Known allergy to drugs that may be used in the study;
• Unable to comply with the trial protocol or follow-up requirements; Or the researcher believes that participating in the trial may result in patients facing greater risks.