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Completed

NCT Number: NCT01135706

Fractal Analysis of the Pulmonary Arterial Tree in Pulmonary Hypertension

The investigators propose to confirm that normotensive and hypertensive pulmonary arteries are fractal, as well as define if the FD correlates to disease severity when compared to available data such as six-minute walk and right heart catheterization measurements.

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Key information

Conditions

Pulmonary Hypertension Cardiovascular Diseases Hypertension Hypertension, Pulmonary Lung Diseases Respiratory Tract Diseases Vascular Diseases

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

The Ohio State University Medical Center

Columbus, Ohio, 43210, United States

About this study

Pulmonary hypertension (PH) is an insidious disorder that can occur in isolation or as a result of various other pulmonary and systemic conditions. If left untreated PH may progress to right heart failure and death. Numerous tests are suggestive but not diagnostic of PH including cardiac echo, pulmonary function testing and chest x-ray. Definitive diagnosis requires right heart catheterization that is invasive, costly and time consuming. The fractal dimension (FD) is an index of the space-filling properties of an object so that the closer the dimension is to the topological dimension in which the object is embedded, the greater the space filling properties. No investigations have been performed to analyze the fractal dimension of pulmonary arteries in patients with PH. We propose to confirm that normotensive and hypertensive pulmonary arteries are fractal, as well as define if the FD correlates to disease severity when compared to available data such as six-minute walk and right heart catheterization measurements.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Patients having a right heart catheterization and CT pulmonary angiogram

Exclusion criteria

  • None

Treatment and study plan

No intervention

Other

This study does not include an intervention but is observational in nature.

Primary outcomes

  1. FD of the pulmonary artery in patients with PH will be lower when compared to patients without PH.

    Time frame: 24 Months

Secondary outcomes

  1. FD will correlate with the degree of PH as quantified by the MPAP obtained during RHC.

    Time frame: 24 Months

  2. FD will correlate with the functional capacity of the PH patients as quantified by distance during six-minute walk and NYHA functional class.

    Time frame: 24 Months

Sponsors and collaborators

Lead sponsor

Ohio State University

Other

Registry information

Official study title

Fractal Analysis of the Pulmonary Arterial Tree in Pulmonary Hypertension.

Important dates

Study start
2010
Primary completion
2012
Study completion
2012
First posted
Jun 3, 2010
Registry last updated
Nov 1, 2012

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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