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Completed

NCT Number: NCT07655973

Foot Intensive Rehabilitation With Perturbation Based Training in Ankle Sprain Patients

To determine the foot-intensive rehabilitation with and without perturbation-based training on pain reduction, range of motion improvement, balance enhancement, and functional instability in patients recovering from ankle sprains NULL HYPOTHESIS There will be no significant difference in the effectiveness of foot-intensive rehabilitation with perturbation-based training compared to foot-intensive rehabilitation alone in reducing pain, improving range of motion, enhancing balance, or reducing functional instability among patients recovering from ankle sprains.

ALTERNATE HYPOTHESIS There will be a significant difference in pain reduction, range of motion improvement, balance enhancement, and reduction in functional instability between patients undergoing foot- intensive rehabilitation with perturbation-based training compared to those undergoing foot-intensive rehabilitation.

Study Design:

It will be a Randomized Clinical Trial

Study Population:

Ankle Sprain Both groups will undergo the assigned interventions for the duration of 6 weeks under the supervision of trained physical therapists or healthcare professionals. The interventions will aim to address pain reduction, range of motion improvement, balance enhancement, and reduction in functional instability among participants recovering from ankle sprains.

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Key information

Age range

18 year–35 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Pakistan Sports Board

Lahore, Punjab Province, 54000, Pakistan

About this study

Group A: Foot-Intensive Rehabilitation with Perturbation-Based Training

Foot-Intensive Rehabilitation:

Participants in Group A will undergo a structured rehabilitation program focused on addressing ankle sprains and improving foot-specific impairments. This program will typically include:

  • Therapeutic Exercises: Range of motion exercises, strengthening exercises for foot and ankle muscles, proprioceptive training, and flexibility exercises tailored to individual needs.
  • Manual Therapy: Hands-on techniques performed by a physical therapist or trained personnel to address soft tissue restrictions, joint mobilization, and mayofascial release.
  • Modalities: Use of modalities like ice, heat, ultrasound, or electrical stimulation for pain relief and enhancing tissue healing.
  • Functional Training: Specific drills and activities mimicking daily tasks or sports- related movements to improve functional capacity.

Perturbation-Based Training: In addition to the foot-intensive rehabilitation program, participants will undergo perturbation-based training sessions:

  • Balance Challenges: Engaging in exercises on unstable surfaces (e.g., balance boards, foam pads) or using devices inducing controlled instability to challenge balance and neuro- muscular control.
  • Dynamic Movements: Performing controlled perturbations or sudden movements to elicit adaptive responses and improve reactive balance strategies.
  • Progression: Gradual progression of difficulty and complexity in perturbation-based exercises based on individual tolerance and improvement.

Group B: Foot-Intensive Rehabilitation without Perturbation-Based Training

Foot-Intensive Rehabilitation:

Participants in Group B will receive the same structured rehabilitation program focusing on foot- intensive exercises as in Group A. This program includes similar components such as therapeutic exercises, manual therapy, modalities, and functional training targeting ankle sprain recovery and foot-specific impairments.

Both groups will undergo the assigned interventions for the duration of 6 weeks under the supervision of trained physical therapists or healthcare professionals

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • • Gender: male /female
  • Participants aged 18 to 35 years old.
  • Diagnosis of an ankle sprain (within 4 weeks of injury).
  • No prior history of severe ankle fractures or surgeries(Hoch et al., 2023)

Exclusion criteria

  • Presence of severe or complex ankle fractures requiring surgical intervention.
  • Conditions other than ankle sprain like neuropathy that affect balance or cutaneous sensation.
  • Neurological disorders impacting balance or proprioception.
  • Pregnancy or planning to become pregnant during the study period(Hoch et al., 2023)

Treatment and study plan

Foot-Intensive Rehabilitation

Other

Foot-Intensive Rehabilitation

This program will typically include:

  • Therapeutic Exercises: Range of motion exercises, strengthening exercises for foot and ankle muscles, proprioceptive training, and flexibility exercises tailored to individual needs.
  • Manual Therapy: Hands-on techniques performed by a physical therapist or trained personnel to address soft tissue restrictions, joint mobilization, and mayofascial release.
  • Modalities: Use of modalities like ice, heat, ultrasound, or electrical stimulation for pain relief and enhancing tissue healing.
  • Functional Training: Specific drills and activities mimicking daily tasks or sports- related movements to improve functional capacity.

Foot-Intensive Rehabilitation + Perturbation-Based Training

Other

In addition to the foot-intensive rehabilitation program, participants in experimental group will undergo perturbation-based training sessions:

  • Balance Challenges: Engaging in exercises on unstable surfaces (e.g., balance boards, foam pads) or using devices inducing controlled instability to challenge balance and neuro- muscular control.
  • Dynamic Movements: Performing controlled perturbations or sudden movements to elicit adaptive responses and improve reactive balance strategies.
  • Progression: Gradual progression of difficulty and complexity in perturbation-based exercises based on individual tolerance and improvement.

Primary outcomes

  1. Numeric pain rate scale (NPRS)

    Time frame: 6 weeks (Baseline, 3rd week, 6th week)

    Patient level of pain will be assessed using this scale. This scale ranges from 0 to 10. 0 indicates "no pain" and 10 indicates "worst pain" (Riley et al., 2019)

  2. Range of Motion (ROM) Measurement

    Time frame: 6 weeks (Baseline, 3rd week, 6th week)

    Goniometer: To measure dorsiflexion, plantarflexion, inversion, and eversion of the ankle joint(Rome & Cowieson, 1996).

  3. Balance Assessment:

    Time frame: 6 weeks (Baseline, 3rd week, 6th week)

    Star Excursion Balance Test (SEBT): Measures reach distances in multiple directions to assess dynamic balance and reach symmetry.(Coughlan et al., 2012)

  4. Functional Instability Measurement

    Time frame: 6 weeks (Baseline, 3rd week, 6th week)

    Cumberland Ankle Instability Tool (CAIT): A questionnaire to assess the severity of functional ankle instability.(ALEXANDRE et al., 2024)

Sponsors and collaborators

Lead sponsor

University of Lahore

Other

Registry information

Official study title

Foot Intensive Rehabilitation With & Without Perturbation Based Training in Patients With Ankle Sprain

Important dates

Study start
2025
Primary completion
2026
Study completion
2026
First posted
Jun 18, 2026
Registry last updated
Jun 30, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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