Skip to main content
OpenTrials
Completed

NCT Number: NCT03706378

Food Modification to Alter Glycaemia and Insulinaemia

The study specifically aims to determine glycemic and insulinemic response of added low GI ingredients, beta-glucan, resistant starch and isomaltulose to foods.

Completed

Looking for future studies?

Notify Me

Key information

Age range

21 year–40 year

Sex eligibility

Male

Study type

Interventional

Phase

Not applicable

Primary location

Clinical Nutrition Research Centre

Singapore, 117599

About this study

There will be a total of 9 test sessions and each session will last up to 3 hours. At each test session, the following procedures will be performed: two finger-prick blood samples, five minutes apart to measure baseline blood glucose and insulin concentrations. Subject will be served the test food and to consume within15 minutes. Following the test meal, blood samples will be collected at the following time points: 15, 30, 45, 60, 90, 120, 150 and 180min for glucose measurements and insulin measurements will be collected at 30, 60, 90, 120, 150 and 180min.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Healthy Males
  • Chinese ethnicity
  • Age ≥21 and ≤ 40 years
  • Body mass index between 18.5 to 25 kg/m2
  • Normal blood pressure ≤140/90 mmHg
  • Fasting blood glucose <6.0 mmol/L
  • In general good health

Exclusion criteria

  • Current smoker
  • Have metabolic diseases (such as diabetes, hypertension etc)
  • Have glucose-6-phosphate dehydrogenase deficiency (G6PD deficiency)
  • Have medical conditions and/or taking medications known to affect glycaemia (glucocorticoids, thyroid hormones, thiazide diuretics)
  • Have an ongoing infection or currently undergoing treatment at the time of screening
  • Have known Chronic infection or known to suffer from or have previously suffered from or is a carrier of Hepatitis B Virus (HBV), Hepatitis C Virus (HCV), Human Immunodeficiency Virus (HIV)
  • Have active Tuberculosis (TB) or currently receiving treatment for TB
  • Intolerances or allergies to any foods
  • Partake in sports at the competitive and/or endurance levels
  • Intentionally restrict food intake

Treatment and study plan

Glucose Reference 1

Other

Glucose contains 50g of available carbohydrates

Glucose Reference 2

Other

Glucose contains 50g of available carbohydrates

Glucose Reference 3

Other

Glucose contains 50g of available carbohydrates

Wheat Yellow Noodle

Other

Wheat Yellow Noodle will contain 50g of available carbohydrate

Beta-glucan yellow Noodle

Other

Beta-glucan yellow noodle will contain 50g of available carbohydrate

Rice Roll

Other

Rice Roll will contain 50g of available carbohydrate

Rice Roll with resistant starch

Other

Rice Roll fortified with resistant starch will contain 50g of available carbohydrate

Sucrose Jelly

Other

Jelly and bread will contain 50g of available carbohydrate. The jelly will contain 25g of sucrose

Isomaltulose Jelly

Other

Jelly and bread will contain 50g of available carbohydrate. The jelly will contain 25g of Isomaltulose

Primary outcomes

  1. Glucose

    Time frame: up to 180 minutes

    Blood glucose will be collected using finger prick method and analysed using Hemocue analyser

  2. Insulin

    Time frame: up to 180 minutes

    Blood glucose will be collected using finger prick method and analysed using Cobas analyser

Sponsors and collaborators

Lead sponsor

Singapore Institute of Food and Biotechnology Innovation

Other Gov

Collaborators

  • Health Promotion Board, Singapore

Registry information

Important dates

Study start
2017
Primary completion
2019
Study completion
2019
First posted
Oct 16, 2018
Registry last updated
May 13, 2019

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.