Food and the Brain

The proposed study will examine the role of reward and emotion in women with and without a history of binge eating. It is important to understand how the brain responds to reward and emotion in binge eating in order to identify different pathways toward binge eating and provide individualized targets for treatment. This is particularly important in light of the fact that for many patients, the current treatments for binge eating are not effective.

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Key information

Conditions

Binge Eating Bulimia Hyperphagia Pathological Conditions, Signs and Symptoms Signs and Symptoms Signs and Symptoms, Digestive

Age range

18 year–35 year

Sex eligibility

Female

Study type

Observational

Primary location

Stanford University, Department of Psychiatry

Stanford, California, 94305, United States

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Female
Ages 18-35
with or without current binge eating behaviors

Exclusion criteria

Any contraindication for MRI (orthodontia, vascular stents, metallic ear tubes, metal implants, piercings, etc).
substance abuse
traumatic brain injury
BMI < 18.5
pregnant women

Treatment and study plan

Primary outcomes

Brain activity during rest

Time frame: Baseline

Functional magnetic resonance imaging will be used to measure brain activity at rest and connectivity between brain regions will be examined.
Brain activity during emotion conflict

Time frame: Baseline

Functional magnetic resonance imaging will be used to measure brain activity during a task where participants respond to images of faces with emotional expressions overlaid with an emotion word written in text. We will focus on brain response during this task when emotion face vs word are in conflict.
Brain activity during monetary wins and losses

Time frame: Baseline

Functional magnetic resonance imaging will be used to measure brain activity during a game where participants can win or lose money if they respond to a shape on the computer screen. Brain response during wins and losses will be examined.

Sponsors and collaborators

Lead sponsor

Stanford University

Other

Registry information

Official study title

Emotion and Reward Processing in Binge Eating

Important dates

Study start: 2016
Primary completion: 2020
Study completion: 2020
First posted: Apr 19, 2016
Registry last updated: Oct 20, 2020

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed