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OpenTrials
Completed

NCT Number: NCT04649138

Fomepizole Dosing During Continuous Renal Replacement Therapy (CRRT)

The project is a prospective observation study of patients with suspected or confirmed toxic alcohol poisoning treated with fomepizole and continuous renal replacement therapy (CRRT)

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Key information

Conditions

Toxic Alcohol Poisoning

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Oslo University Hospital

Oslo, Norway

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Patients (over 18 year) with suspected or confirmed toxic alcohol poisoning treated with fomepizole and CRRT.

Exclusion criteria

  • Patients who wish to withdraw from the study

Treatment and study plan

Primary outcomes

  1. Measure minimum plasma concentration of fomepizole

    Time frame: through study completion, up to 72 hours

    Plasma samples will be obtained up to every hour and before fomepizole is given

Secondary outcomes

  1. Continuous renal replacement therapy (CRRT) clearance of fomepizole

    Time frame: through study completion, up to 72 hours

    Plasma and dialysat samples will be obtained up to every hour

  2. Determine saturation/sieving coefficient of fomepizole

    Time frame: through study completion, up to 72 hours

    Plasma and dialysat samples will be obtained up to every hour

Sponsors and collaborators

Lead sponsor

Oslo University Hospital

Other

Collaborators

  • Louisiana State University Health Sciences Center Shreveport

Registry information

Important dates

Study start
2019
Primary completion
2020
Study completion
2020
First posted
Dec 2, 2020
Registry last updated
Apr 4, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.