Follow-Up for Study Participants Treated With an Allogeneic CAR T-Cell Product

An observational, long-term follow up (LTFU) study of participants who received an allogeneic CAR T product in a prior clinical study. Participants will be followed for 15 years after their last infusion of an allogenic CAR T cell product.

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Key information

Conditions

Hematologic Malignancies Hematologic Diseases Hematologic Neoplasms Hemic and Lymphatic Diseases Neoplasms Neoplasms by Site Solid Tumors

Sex eligibility

All sexes

Study type

Observational

Primary location

Circuit Clinical

Buffalo, New York, 14203, United States

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Received an allogenic CAR T-cell product infusion to treat an oncologic condition in a previous Allogene or Servier sponsored clinical study

Exclusion criteria

Less than 12 months of follow up after the last allogeneic CAR T-cell product, unless approved by the Allogene Medical Monitor

Treatment and study plan

Primary outcomes

Incidence of delayed adverse events potentially related to allogeneic CAR T-cell product and allogeneic CAR T-cell product-related SAEs

Time frame: Up to 15 years post treatment with allogeneic CAR T-cell product
Overall survival (OS)

Time frame: Up to 15 years post treatment with allogeneic CAR T cell product
Presence of replication competent lentivirus (RCL) in blood

Time frame: Up to 15 years post treatment with allogeneic CAR T cell product

Sponsors and collaborators

Lead sponsor

Allogene Therapeutics

Industry

Registry information

Official study title

Long Term Follow up Study for Participants Treated With an Allogeneic CAR T-Cell Product in a Prior Clinical Study

Important dates

Study start: 2025
Primary completion: 2039
Study completion: 2039
First posted: Apr 13, 2025
Registry last updated: Apr 13, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Enrolling by Invitation