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OpenTrials
Active, Not Recruiting

NCT Number: NCT03624751

Follow up for Patients With Thyroid Cancer Planed for Radioiodine Scan or Treatment

The prevalence of thyroid cancer has increased in recent decades. Patients with thyroid cancer need to choose between Thyrogen® injection and Eltroxin® withdrawal before radioiodine therapy or scan. This is a prospective, observational study, aiming to observe the difference of metabolic profiles between patients choose Thyrogen® injection and Eltroxin® withdrawal.

Active, Not Recruiting

This study is active but is not currently recruiting participants.

Key information

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Division of Endocrinology and Metabolism in Taichung Veterans General Hospital

Taichung, 407, Taiwan

About this study

  • Objective: To observe the difference between Thyogen® injection or Eltroxin® withdrawal on metabolic profile.
  • Background and method:: The prevalence of thyroid cancer has increased in recent decades. Patients with thyroid cancer need to choose between Thyrogen® injection and Eltroxin® withdrawal before radioiodine therapy or scan. This is a prospective, observational study, aiming to observe the difference of metabolic profiles between patients choose Thyrogen® injection and Eltroxin® withdrawal.

Inclusion : Patient number: 500人

Inclusion criteria

  • Patients with diagnosis of thyroid cancer。
  • Patients who need radioiodine therapy or scan。

Exclusion criteria

  • Patients cannot cooperate with blood test.。
  • Patients cannot cooperate with radioiodine therapy。 Study design: Prospective, observational study。

Method: We will collect 20cc blood and 20 cc urine before and after radioiodine therapy during each visit (total 3 visits) and check lipid profiles, glucose profiles and inflammation markers. We will compare the difference between results of patients undergoing Thyrogen® injection and Eltroxin® withdrawal.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Patients with diagnosis of thyroid cancer。
  • Patients who need radioiodine therapy or scan。

Exclusion criteria

  • Patients cannot cooperate with blood test.。
  • Patients cannot cooperate with radioiodine therapy。

Treatment and study plan

Radioiodine

Radiation

Patients with thyroid cancer need to choose between Thyrogen® injection and Eltroxin® withdrawal before radioiodine therapy or scan.

Primary outcomes

  1. Zung's Self-reported depression scale

    Time frame: 1 month

    Depression symtpoms

Secondary outcomes

  1. Brain-derived neurotrophic factor

    Time frame: 1 month

    BDNF

  2. orexin

    Time frame: 1 month

    An associated factor for depression

  3. Body composition

    Time frame: 1 months

    Fat component percentage to lean mass percentage ratio

  4. VCAM-1

    Time frame: 1 months

    adhesion molecules

  5. CRP

    Time frame: 1 months

    inflammation marker

  6. Metabolic syndrome

    Time frame: 1 months

    The number of conponents for metabolic syndrome

  7. Insulin resistance

    Time frame: 1 month

    HOMA-IR

Sponsors and collaborators

Lead sponsor

Taichung Veterans General Hospital

Other

Registry information

Important dates

Study start
2018
Primary completion
2028
Study completion
2030
First posted
Aug 10, 2018
Registry last updated
May 1, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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