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NCT Number: NCT06839274

Follicular Volume at the Time of Final Oocyte Maturation in Poor Responders, and Its Correlation With Oocyte Maturity

Women with a severely diminished ovarian reserve and monofollicular growth are at a higher risk of premature ovulation as well as poor quality oocytes. Our group showed previously that women with severely diminished ovarian reserve benefit from receiving the final oocyte maturation at smaller follicle sizes in terms of reducing the risk of premature ovulation and finding mature oocytes even out of small size follicles.

Adding the measurement of the follicular volume at the time of final oocyte maturation might provide more information on the proper timing of trigger administration compared to the follicular size alone, hormonal profile as well as previous stimulation attempts. Setting a cutoff value of follicular volume for trigger might help to avoid premature ovulation and possibly increase the chances of ending up with a euploid embryo.

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Key information

Conditions

OVARIAN STIMULATION

Age range

18 year–48 year

Sex eligibility

Female

Study type

Observational

Primary location

ART Fertility Clinics

Abu Dhabi, Abu Dhabi Emirate, 60202, United Arab Emirates

Location status: Recruiting

Location contact

Jonalyn Edades, MBA

CONTACT

[email protected]

00971526408688

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Reproductive age group: 18 -48
undergoing ovarian stimulation for oocyte vetrification
undergoing IVF/ ICSI with PGT-A / PGT-M / PGT- Sr
less than or equal to 3 AFC on initiation of stimulation
follicular phase stimulation

Exclusion criteria

surgically retrieved sperm

Treatment and study plan

Transvaginal ultrasound

Other

The only additional measure will be the measurement of the follicle volumes on the day of trigger and before oocyte pick up procedure. This will be performed at the same time as the pre Oocyte pick up ultrasound prior to the patient admission to the recovery room for preparation. The ultrasound that will be used already has a pre build program that calculates the follicular volume automatically and hence not extending the ultrasound time.

Primary outcomes

the investigators will see the corellation between the follicular volume at the time of trigger with the oocyte maturity in patients with less than four follicles of a follicle size of at least 11 mm .

Time frame: 1 year

The objective of this study is to evaluate the relationship between follicular volume at the time of trigger and oocyte maturity in patients undergoing assisted reproductive techniques, specifically those with fewer than four follicles of at least 11 mm in size. This study aims to determine whether follicular volume just before trigger is a significant predictor of oocyte maturation. By focusing on this specific patient group, the study seeks to provide insights that could inform treatment strategies and improve outcomes in assisted reproductive technology.

Study contacts

Contact information is provided by the study sponsor or research team.

Jonalyn Edades, MBA

CONTACT

[email protected]

+97126528000

Jonalyn Edades, MBA

CONTACT

[email protected]

+97126528000

Sponsors and collaborators

Lead sponsor

ART Fertility Clinics LLC

Other

Registry information

Important dates

Study start: 2025
Primary completion: 2026
Study completion: 2026
First posted: Feb 21, 2025
Registry last updated: Jun 25, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

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This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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Recruiting