fMRI Cholinergic Mechanisms in Schizophrenia

This study aims to determine how clozapine treatment improves neuronal measures of sensory gating in subjects with schizophrenia.

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Key information

Conditions

Schizophrenia Mental Disorders Schizophrenia Spectrum and Other Psychotic Disorders

Age range

18 year–60 year

Sex eligibility

All sexes

Study type

Observational

Primary location

VA Eastern Colorado Health Care System, Denver

Denver, Colorado, 80220, United States

About this study

This study will use functional magnetic resonance imaging (fMRI) to study patients treated with risperidone, a commonly used neuroleptic that does not improves sensory gating, to those treated with clozapine to determine which brain areas are involved in clozapine's normalization of sensory gating in schizophrenia.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Diagnosis of schizophrenia
age 18-60 yrs

Exclusion criteria

claustrophobia
weight > 250 lbs
metal in body other than dental fillings

Treatment and study plan

Primary outcomes

Neuronal Response During Sensory Gating

Time frame: Immediate

Neuronal response (blood oxygenation level dependent functional magnetic resonance imaging signal, relative to the global mean) during sensory gating. Sensory gating is defined as the process of filtering out unnecessary environmental stimuli.

Sponsors and collaborators

Lead sponsor

US Department of Veterans Affairs

Fed

Registry information

Important dates

Study start: 2008
Primary completion: 2011
Study completion: 2011
First posted: Aug 31, 2010
Registry last updated: May 15, 2015

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed