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Completed

NCT Number: NCT00714779

Fluoxetine vs. Brief Psychotherapy for Major Depression

In this study we compare two treatments for major depression - fluoxetine and brief psychodynamic psychotherapy. In addition to more traditional outcome measures, we also measure the densities of 5HT-1A and D-2 receptors before and after the treatment. The main hypothesis is that brief psychotherapy is as effective as fluoxetine.

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Key information

Conditions

Major Depressive Disorder Depressive Disorder Depressive Disorder, Major Mental Disorders Mood Disorders

Age range

20 year–60 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

About this study

This study is a randomized comparison of two treatments for major depression - fluoxetine and brief psychodynamic psychotherapy. The patients are recruited from occupational health services and suffer from mild to moderate major depressive disorder. The treatments last for 16 weeks. The main outcome measures include HAM-D, BDI, SOFAS, Rand-36. In addition to more traditional outcome measures, we also measure the densities of 5HT-1A and D-2 receptors before and after the treatment using Positron Emission Tomography (PET) . The main hypothesis is that brief psychotherapy is as effective as fluoxetine, but differences between the treatments are seen in PET scanning.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • MDD (mild to moderate)
  • HDRS 15 or more, age 20-60 years
  • No treatment for preceding 4 months
  • No DSM-IV axis I or II comorbidity
  • No severe somatic illness
  • No contraindications for fluoxetine treatment

Treatment and study plan

Fluoxetine

Drug

20-40 mg / day orally

Short-term psychodynamic psychotherapy

Behavioral

1 session / week for 16 weeks

Primary outcomes

  1. HAM-D

    Time frame: 0, 16 weeks, one year

Sponsors and collaborators

Lead sponsor

University of Turku

Other

Collaborators

  • Finnish State Grant
  • KELA

Registry information

Official study title

Fluoxetine vs. Brief Psychotherapy in the Treatment of Major Depression - a Randomized Comparative Study

Important dates

Study start
2000
Primary completion
2004
Study completion
2004
First posted
Jul 14, 2008
Registry last updated
Jul 14, 2008

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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