Fluid Intake in Kidney Failure

Patients with renal impairment are usually advised to increase their fluid intake. There is currently, however, no evidence supporting this recommendation. In contrast,high fluid intake could be dangerous if urine excretion is reduced. In this study the researchers investigate whether increasing fluid intake from 2 to 4 litres per day has any influence on long-term renal outcome.

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Key information

Conditions

Chronic Renal Failure Chronic Disease Disease Attributes Female Urogenital Diseases Female Urogenital Diseases and Pregnancy Complications Kidney Diseases Kidney Failure, Chronic Kidney Transplantation Male Urogenital Diseases Pathologic Processes Pathological Conditions, Signs and Symptoms Renal Insufficiency Renal Insufficiency, Chronic Urogenital Diseases Urologic Diseases

Age range

18 year–70 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Medical University Vienna

Vienna, 1090, Austria

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Patients with native kidney disease or chronic kidney transplant failure
An effective glomerular filtration rate (eGFR) according the MDRD formula between 20 and 75ml/min/1.73m2
Ejection fraction >20%
Absence of liver cirrhosis or ascites
No evidence of active glomerulonephritis or immunosuppressive therapy if native kidney disease
Acute transplant rejection
Urinary protein excretion below 3g/d
Age between 18 and 70 years.

Exclusion criteria

Therapy resistant edema
Severe pulmonary disease
Mean arterial pressure (MAP) > 120 mm Hg
Pregnancy
Kidney transplantation within three months prior to randomization

Treatment and study plan

high fluid intake

Behavioral

fluid intake of 4 litres per day

normal fluid intake

Behavioral

Fluid intake of 2 litres per day

Sponsors and collaborators

Lead sponsor

Medical University of Vienna

Other

Registry information

Official study title

The Effect of Increased Fluid Intake on Chronic Renal Failure

Important dates

First posted: Feb 12, 2009
Registry last updated: Feb 13, 2009

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed