Skip to main content
OpenTrials
Completed

NCT Number: NCT01211184

Fluid and Nutrition in Elective Hip Surgery

The purpose of this study is to determine whether fluid or glucose administration before hip replacement surgery minimizes postoperative muscle breakdown (catabolism), fatigue and disturbances in carbohydrate metabolism.

Completed

Looking for future studies?

Notify Me

Key information

Conditions

Hip Surgery Corrective

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Södertälje Hospital

Södertälje, 15286, Sweden

About this study

  • How can a simple and safe way to measure the body's tendency to transient diabetes associated with surgery?
  • Can fluid or glucose administration before elective hip surgery, minimizing post-operative muscle breakdown (catabolism), fatigue and disturbances in carbohydrate metabolism?

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Patient scheduled for hip surgery. Exclusion Criteria: Endocrinological disorders.

Treatment and study plan

Water administration

Dietary Supplement

patients undergo hip surgery after receiving 800 ml water by mouth in the morning before the surgery.

Other names: Tap water

Carbohydrate drink

Dietary Supplement

800 ml carbohydrate drink by mouth the evening before surgery and 400 ml carbohydrate drink by mouth 2 hours before surgery

Other names: PreOp Nutricia ( Nutricia Nordic AB)

Fasting.

Behavioral

The patient is fasting from midnight before the surgery.

Primary outcomes

  1. Change in Insulin Sensitivity (Percent)

    Time frame: Day before surgery (approximately 3 PM) and in the morning after surgery (approx. 7.30 AM).

    Insulin sensitivity (micro-mol per kg per minute glucose uptake) was calculated based on an intravenous glucose tolerance test (Theor Biol Med Model 2011, 8: 12) on the day before surgery. The percent change was taken as (day after - day before) / day before

Secondary outcomes

  1. Muscle Catabolism

    Time frame: From the morning after surgery (07.30) up to the morning two days after sthe surgery (07.30)

    Assessed by the ratio of 3-methylhistidine/creatinine in excreted urine (unit: mmol/mmol).This is an amino acid unique to muscle that does not undergo intermediary metabolism, meaning that its urinary excretion is an index of the degree of muscle catabolism.

Sponsors and collaborators

Lead sponsor

Sodertalje Hospital

Other

Registry information

Important dates

Study start
2008
Primary completion
2009
Study completion
2009
First posted
Sep 29, 2010
Registry last updated
Nov 25, 2016

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Related clinical trials

Published trials that share one or more normalized conditions with this study.