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NCT Number: NCT05908266

Flexible Reaching Control in Parkinson Disease

Current research and theories have highlighted that the parameters linked to movement planning, e.g. the decision to select a movement goal, and adaptation, e.g. the ability to update control dependent on a novel dynamical context, are update quickly and within an ongoing movement in the general population. In parallel, it has been suggested that the evaluation of movement costs is a function of the basal ganglia, and it is impaired in Parkinson disease (PD). Here the investigators want to test whether these mechanisms also alter the ability of patients to update control during an ongoing action. A positive result would confirm that movement-related costs and dynamical representations depend on the integrity of the basal ganglia, in contrast a negative result would indicate that the deficit in PD is more specifically related to movement initiation, which would invite one to reconsider the cause of bradykinesia in this population.

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Key information

Conditions

Parkinson Disease Basal Ganglia Diseases Brain Diseases Central Nervous System Diseases Movement Disorders Nervous System Diseases Neurodegenerative Diseases Parkinsonian Disorders Synucleinopathies

Age range

18 year–99 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Université catholique de Louvain

Louvain-la-Neuve, 1348, Belgium

Location status: Recruiting

Location contact

André Mouraux, PhD

CONTACT

[email protected]

+32 2 764 54 47

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Ability to perform the task (assessed during the experiment)

Exclusion criteria

  • Inability to perform the task (motor) or to understand the task requirements (cognitive)

Treatment and study plan

Reaching movements

Other

Participants will be instructed to perform reaching movements by moving the handle of a robotic arm mounted with a virtual reality display.

Disease Assessment

Other

Disease stage assessed by trained professionals

Primary outcomes

  1. Kinematics

    Time frame: Measured during the entire experiment (an average of 4.5 years)

    Position of the handle as a function of time. Units are millimetres

  2. Surface Electromyogram

    Time frame: Measured during the entire experiment (an average of 4.5 years)

    Surface recordings of muscles activities from the main muscles involved in movement production. Units are volts

  3. Applied forces

    Time frame: Measured during the entire experiment (an average of 4.5 years)

    Forces applied by participants on the robotic handle. Units are Newtons

Study contacts

Contact information is provided by the study sponsor or research team.

André Mouraux, PhD

CONTACT

[email protected]

+32 2 764 54 47

Frédéric Crevecoeur, PhD

CONTACT

[email protected]

Sponsors and collaborators

Lead sponsor

Université Catholique de Louvain

Other

Registry information

Official study title

Behavioural Study of Reaching Control in Healthy Volunteers and Volunteers With Parkinson Disease in Dynamical Context

Acronym: REACH-PD

Important dates

Study start
2023
Primary completion
2027
Study completion
2027
First posted
Jun 18, 2023
Registry last updated
Jun 18, 2023

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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